5541-64-0

Basic information

• Product Name: 2-(4-nitrophenyl)quinoxaline
• Synonyms: 2-(4-Nitrophenyl)quinoxaline; 2-(4-Nitro-phenyl)-quinoxaline; Quinoxaline, 2-(4-nitrophenyl)-
• CAS NO: 5541-64-0
• Molecular Formula: C₁₄H₉N₃O₂
• Molecular Weight: 251.2402
• Mol File: 5541-64-0.mol
• Article Data: 33

Chemical Properties

• Boiling Point: 438.3°C at 760 mmHg
• Flash Point: 218.9°C
• Density: 1.342g/cm³
• Vapor Pressure: 1.8E-07mmHg at 25°C
• Refractive Index: 1.688
• CAS DataBase Reference: 2-(4-nitrophenyl)quinoxaline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-nitrophenyl)quinoxaline(5541-64-0)
• EPA Substance Registry System: 2-(4-nitrophenyl)quinoxaline(5541-64-0)

Safety Data

• Hazardous Substances Data: 5541-64-0(Hazardous Substances Data)

Usage

General Description

2-(4-nitrophenyl)quinoxaline is a chemical compound with the molecular formula C14H9N3O2. It belongs to the quinoxaline class of compounds and is characterized by a quinoxaline ring structure with a 4-nitrophenyl group attached. 2-(4-nitrophenyl)quinoxaline is commonly used in organic synthesis and can be found in various research and industrial applications. It exhibits unique chemical properties that make it useful in the development of pharmaceuticals, agrochemicals, and materials. Its distinct structure and reactivity make it a valuable building block for the synthesis of complex organic molecules with potential applications in pharmaceuticals and materials science.

Upstream product

• 99-81-0 4-Nitrophenacyl bromide 
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• 4974-57-6 4-nitrophenylglyoxal 
• 46417-99-6 2-nitro-1-(4-nitrophenyl)-1-ethanone 
• 5021-43-2 2-phenylquinoxaline 
• 39214-83-0 3-(4-nitrophenyl)isoxazol-5(4H)-one 
• 25233-82-3 1-(4-nitrophenyl)-4-phenyl-2-butene-1,4-dione 
• 100-19-6 (4-nitrophenyl)ethanone 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 555-16-8 4-nitrobenzaldehdye 
• 1374568-15-6 2,2-diiodo-1-(4-nitrophenyl)ethanol 
• 64611-67-2 2-hydroxy-1-(4-nitrophenyl)ethanone 
• 1434751-60-6 2-benzoyl-4-(4-nitrophenyl)-1-phenylbut-2-ene-1,4-dione 
• 100-12-9 4-ethylnitrobenzene 

Downstream Products

• 81622-74-4 4-(quinoxalin-2-yl)aniline 
• 855933-25-4 N-acetyl-sulfanilic acid-(4-quinoxalin-2-yl-anilide) 
• 1252875-96-9 (S)-2-(4-nitrophenyl)-1,2,3,4-tetrahydroquinoxaline 
• 1444302-56-0 2-(2-fluoro-4-nitrophenyl)quinoxaline 

Relevant articles and documents

Silica supported dodecatungstophosphoric acid (DTP/SiO2): An efficient and recyclable heterogeneous catalyst for rapid synthesis of quinoxalines

A facile synthesis of quinoxalines by the cyclocondensation of substituted phenacyl bromides with o-pheneylenediamines using silica-supported dodecatungstophosphoric acid (DTP/SiO2) as a recyclable heterogeneous catalyst is unveiled in this res

Iridium-Catalyzed Carbenoid Insertion of Sulfoxonium Ylides for Synthesis of Quinoxalines and β-Keto Thioethers in Water

Sulfoxonium ylides as safe carbene precursors are described for iridium-catalyzed carbene insertions and annulation, providing a facile and green approach to access a variety of quinoxaline derivatives in water. This water-mediated method also allows the preparation of β-keto thioethers under mild condition.

Green synthesis of novel quinoxaline sulfonamides with antibacterial activity

A facile and efficient method was investigated for the synthesis of different quinoxalines by the reaction of o-phenylene diamine and 2-bromoacetophenones. This procedure was carried out in ethanol under catalyst-free conditions. Several sulfonamides were synthesized from 2-(4-methoxyphenyl)-quinoxaline in two steps. At first chlorosulfonation of 2-(4-methoxyphenyl) quinoxaline was done using chlorosulfonic acid and led to 2-methoxy-5-quinoxalin-2-yl-benzenesulfonyl chloride. Then quinoxaline sulfonamides were synthesized by the reaction of quinoxaline sulfonyl chloride with different aromatic amines under solvent-free conditions. All the products were obtained in excellent yields after an easy work-up and were evaluated for antibacterial activities against Staphylococcus spp. and Escherichiacoli bacteria.