55435-65-9 Usage
Originator
Acodazole
Hydrochloride
,ZYF Pharm
Uses
Antineoplastic.
Manufacturing Process
An 82.0 g (0.5 mole) of 5-nitrobenzimidazole in 900 ml of ethanol was
reduced over 4.0 g of 5% Pd/C catalyst containing 50% H2O. After filtration of
the catalyst, 65.0 g (0.5 mole) of ethyl acetoacetate, 20.0 g of anhydrous
calcium sulfate, and 0.5 ml of HOAc was added. After filtration, the solution
was concentrated in vacuo till a solid remained. The product was filtered and
washed with fresh ethanol and air-dried. The yield of ethyl 3-(5-
benzimidazolylamino)crotonate was 84.0 g (69%), melting point 160°-162°C.
40.0 g of ethyl 3-(5-benzimidazolylamino)crotonate was added to 80 ml of
boiling Dowtherm? and the boiling was continued for 5 min. The product
separated upon cooling. The product was filtered, washed with Dowtherm?
and then acetone and air-dried. The yield of 7-methyl-9-imidazo[4,5-
f]quinolinol was 29.0 g (91%), melting point 345°-347°C.
Into a 22 L, 4-necked flask set in a tub and equipped with a stirrer, an air
condenser (drying tube), thermometer, and dropping funnel was placed POCl3
(4590 ml). The 7-methyl-9-imidazo[4,5-f]quinolinol (1062.0 g, 5.33 moles)
was added with no heating effect noted. Dimethylformamide (4690 ml) was
added dropwise over a 2.5 h period at a rate to control the temperature below
85°C. The resulting viscous solution was allowed to stand overnight at room
temperature and then added cautiously to ice to a total volume of ca. 50 L.
The resulting solution was then adjusted to a pH of 7 to 8 by the addition of
NaOH pellets (9771.0 g). More ice was added as needed to keep the
temperature below 45°C. The resulting precipitate was collected by filtration,
washed well by stirring in water (3x20 L) and dried at 60°C to yield 1107.0 g
(95.5%) of 9-chloro-7-methylimidazo[4,5-f]quinolone.
To 500 ml of acetic anhydride was added portionwise, 100.0 g (0.658) of Nmethyl-
p-nitroaniline. Following the addition, the solution was heated on a
steam bath for 2 h, then stirred overnight at room temperature. The white
precipitate of the N-methyl-4-nitroacetanilide was collected by filtration,
washed with ether and air-dried to give 53.0 g, melting point 153°-156°C.
The filtrate was concentrated in vacuum to give another 61.0 g, melting point
150°-154°C.
A mixture of 114.0 g (0.587 m) of N-methyl-4-nitroacetanilide and 800 ml of
ethanol was shaken with hydrogen over one teaspoon of Raney active nickel
catalyst in water. A pressure drop of 127 psi was recorded (calc. 118 psi). The
catalyst was removed by filtration and the ethanol filtrate refluxed overnight
with 127.0 g (0.587 m) of the 9-chloro-7-methylimidazo[4,5-f]quinolone. The
mixture was chilled, filtered, washed with ether and air-dried to give 75.5 g of
9-[p-(N-methylacetamido)anilino]-7-methyl-1-H-imidazo[4,5-f]quinoline hydrochloride sesquihydrate, melting point 315°-318°C (recrystallized from
4,000 ml of MeOH).
By treatment of 9-p-(N-methylacetamido)anilino-7-methyl-1H-imidazo[4,5-
f]quinolone hydrochloride sesquihydrate with NaOH may be produced the 9-p-
(N-methylacetamido)anilino-7-methyl-1H-imidazo[4,5-f]quinolone.
Therapeutic Function
Antineoplastic
Check Digit Verification of cas no
The CAS Registry Mumber 55435-65-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,4,3 and 5 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 55435-65:
(7*5)+(6*5)+(5*4)+(4*3)+(3*5)+(2*6)+(1*5)=129
129 % 10 = 9
So 55435-65-9 is a valid CAS Registry Number.
InChI:InChI=1/C20H19N5O.ClH/c1-12-10-18(19-16(23-12)8-9-17-20(19)22-11-21-17)24-14-4-6-15(7-5-14)25(3)13(2)26;/h4-11H,1-3H3,(H,21,22)(H,23,24);1H
