554445-44-2

Basic information

• Product Name: 4,5-bis(methylsulfonyl)veratrol
• Synonyms: 4,5-bis(methylsulfonyl)veratrol
• CAS NO: 554445-44-2
• Molecular Weight: 294.35
• Mol File: 554445-44-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4,5-bis(methylsulfonyl)veratrol(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-bis(methylsulfonyl)veratrol(554445-44-2)
• EPA Substance Registry System: 4,5-bis(methylsulfonyl)veratrol(554445-44-2)

Safety Data

• Hazardous Substances Data: 554445-44-2(Hazardous Substances Data)

Upstream product

• 91-16-7 1,2-dimethoxybenzene 
• 110190-08-4 1,2-diiodo-4,5-dimethoxybenzene 
• 20277-69-4 sodium methansulfinate 

Downstream Products

• 554445-45-3 4,5-bis(methylsulfonyl)pyrocatechol 

Relevant articles and documents

Synthesis, enantiomeric conformations, and stereodynamics of aromatic ortho-substituted disulfones

Aromatic ortho-disulfone derivatives are readily accessible from diiodide precursors by CuI-mediated reaction with sodium sulfinate salts (DMF, 110°). The sulfonyl substituents adopt in solution and in the solid state two enantiomeric conformations (λ and δ) as evidenced by 31P- and IH-NMR data of the chiral D3-symmetric tris{4,5-bis[(4-methylphenyl)sulfonyl]benzene-1,2-diolato(2-)- κO,κO′}phosphate(v) anion (3a) and 1,2-bis(camphor-10-sulfonyl)-4,5-dimethoxybenzene((=1, 2-bis{{[(1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]- hept-1-y1]methyl}sulfonyl}-4,5-dimethoxybenzene; 6c). X-Ray structure analysis of 1,2-dimethoxy-4,5-bis(methylsulfonyl)benzene (6a) and 1,2-dimethoxy-4,5-bis(4-methylphenyl)sulfonyl]benzene (6b) confirmed in the solid state the preferred chiral orientation of the sulfonyl groups. Dynamic conformational isomerism was detected for 6c in its IH-NMR in the temperature range of 110°, the corresponding free energy being 19.8 kcal mol-1.