55458-49-6

Basic information

• Product Name: Acetamide, N-[[4-(acetyloxy)phenyl]methyl]-
• CAS NO: 55458-49-6
• Molecular Formula: C11H13NO3
• Molecular Weight: 207.229
• Mol File: 55458-49-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Acetamide, N-[[4-(acetyloxy)phenyl]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[[4-(acetyloxy)phenyl]methyl]-(55458-49-6)
• EPA Substance Registry System: Acetamide, N-[[4-(acetyloxy)phenyl]methyl]-(55458-49-6)

Safety Data

• Hazardous Substances Data: 55458-49-6(Hazardous Substances Data)

Upstream product

• 696-60-6 4-aminomethylphenol 
• 75-36-5 acetyl chloride 
• 1004-23-5 4-hydroxy-benzylamine hydrochloride 
• 13031-41-9 4-cyanophenyl acetate 
• 108-24-7 acetic anhydride 
• 75383-64-1 4-acetoxybenzylamine 

Relevant articles and documents

Synthesis and pharmacological evaluation of piperidine (piperazine)-amide substituted derivatives as multi-target antipsychotics

We report the optimisation of a series of novel amide-piperidine (piperazine) derivatives using the multiple ligand approach with dopamine and serotonin receptors. Of the derivatives, compound 11 exhibited high affinity for the D2, 5-HT1A, and 5-HT2A receptors, but low affinity for the 5-HT2C and histamine H1 receptors and human ether-a-go-go-related gene (hERG) channels. In vivo, compound 11 reduced apomorphine-induced climbing, MK-801-induced hyperactivity and DOI-induced head twitching without observable catalepsy, even at the highest dose tested. In addition, it exhibited suppression in a CAR test. Furthermore, in a novel object recognition task, it displayed procognition properties. Therefore, compound 11 is a promising candidate multi-target antipsychotic.

Phenoxyalkylcarboxylic acid compounds and thrombocyte-aggregation inhibition

Phenoxyalkylcarboxylic acid compounds of the formula STR1 wherein R is hydrogen or lower alkyl R1 is alkyl or aryl, aralkyl or aralkenyl radical, the aryl moiety of which can be substituted one or more times by halogen, hydroxyl, trifluoromethyl or lower alkyl, alkoxy or acyl R2 and R3 are individually selected from hydrogen or lower alkyl, and n is 0, 1, 2 or 3 and the physiologically acceptable salts, esters and amides thereof; are outstandingly effective in inhibiting thrombocyte aggregation.