55458-78-1

Basic information

• Product Name: Propanoic acid, 2-[4-(2-aminoethyl)phenoxy]-2-methyl-
• CAS NO: 55458-78-1
• Molecular Formula: C12H17NO3
• Molecular Weight: 223.26800
• Mol File: 55458-78-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Propanoic acid, 2-[4-(2-aminoethyl)phenoxy]-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 2-[4-(2-aminoethyl)phenoxy]-2-methyl-(55458-78-1)
• EPA Substance Registry System: Propanoic acid, 2-[4-(2-aminoethyl)phenoxy]-2-methyl-(55458-78-1)

Safety Data

• Hazardous Substances Data: 55458-78-1(Hazardous Substances Data)

Upstream product

• 600-00-0 ethyl 2-bromoisobutyrate 
• 55458-55-4 ethyl 2-[4-(2-acetaminoethyl)-phenoxy]-2-methyl-propionate 
• 1202-66-0 N-acetyltyramine 
• 29655-46-7 N-benzyloxycarbonyl-2-(4-hydroxyphenyl)ethylamine 

Downstream Products

• 55458-82-7 ethyl 2-[4-(2-aminoethyl)-phenoxy]-2-methylpropionate 

Relevant articles and documents

Generation of secondary alkyl amines on solid support by borane reduction: Application to the parallel synthesis of PPAR ligands

A solid phase parallel synthesis of fibrate PPAR ligands 1 has been developed. The key reaction is a novel borane reduction of resin bound amides that generates secondary amines not accessible by inductive alkylation of primary amines. The FMOC-protected amino-fibrate 2 was loaded onto Sasrin resin via the carboxylic acid. The amine was elaborated by amide bond formation followed by reduction with borane. The resulting secondary amines reacted with aryl isocyanates to generate the fibrates 1 in high yield and purity following cleavage from the solid support.

Phenoxyalkylcarboxylic acid compounds and serum-lipid and triglyceride depressing therapeutic compositions

Novel phenoxyalkylcarboxylic acid compounds of the formula STR1 wherein A is aryl, aryloxy, substituted aryl or substituted aryloxy, wherein the substituents are selected from lower alkyl, lower alkoxy, halogen and haloalkyl; B is a straight-chained or br