55484-11-2

Basic information

• Product Name: Ethanone, 2-chloro-1-(3-pyridinyl)- (9CI)
• Synonyms: Ethanone, 2-chloro-1-(3-pyridinyl)- (9CI);2-Chloro-1-(pyridin-3-yl)ethanone;Chloroacetylpyridine;2-chloro-1-(pyridin-3-yl)ethan-1-one
• CAS NO: 55484-11-2
• Molecular Formula: C₇H₆ClNO
• Molecular Weight: 155.58164
• Product Categories: ACETYLHALIDE
• Mol File: 55484-11-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 272.4°C at 760 mmHg
• Flash Point: 118.5°C
• Appearance: /
• Density: 1.238g/cm³
• Vapor Pressure: 0.00609mmHg at 25°C
• Refractive Index: 1.537
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Ethanone, 2-chloro-1-(3-pyridinyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-chloro-1-(3-pyridinyl)- (9CI)(55484-11-2)
• EPA Substance Registry System: Ethanone, 2-chloro-1-(3-pyridinyl)- (9CI)(55484-11-2)

Safety Data

• Hazardous Substances Data: 55484-11-2(Hazardous Substances Data)

Usage

General Description

"Ethanone, 2-chloro-1-(3-pyridinyl)- (9CI)" is a chemical compound, often referenced in the context of chemical and pharmaceutical research. It has a systematic name of 1-(3-pyridyl)-2-chloroethanone, indicating that it is composed of an ethanone core, a pyridyl component (a basic organic compound with a six-membered ring containing two nitrogen atoms), and a chloro group. Ethanone, 2-chloro-1-(3-pyridinyl)- (9CI) is commonly used in the synthesis of various organic compounds and may play a role in the development of potential therapeutic agents. Its detailed physical and chemical properties, such as its exact boiling point or density, are typically dependent on its specific conditions, such as temperature and pressure.

InChI:InChI=1/C7H6ClNO/c8-4-7(10)6-2-1-3-9-5-6/h1-3,5H,4H2

Upstream product

• 350-03-8 methyl-3-pyridylketone 
• 39972-50-4 2-diazo-1-(pyridine-3-yl)ethan-1-one 
• 61889-48-3 2-chloro-1-(3-pyridinyl)ethanone hydrochloride 

Downstream Products

• 104501-59-9 3-Hydroxyacetylpyridine 
• 30235-27-9 4-(pyridin-3-yl)thiazol-2-amine 
• 61889-51-8 (4-methoxy-phenyl)-(4-pyridin-3-yl-thiazol-2-yl)-amine 
• 61889-50-7 (2-methoxy-phenyl)-(4-pyridin-3-yl-thiazol-2-yl)-amine 
• 61889-49-4 N-phenyl-4-(3-pyridinyl)-1,3-thiazol-2-amine 
• 61889-59-6 benzyl-(4-pyridin-3-yl-thiazol-2-yl)-amine 
• 61889-56-3 (4-chloro-phenyl)-(4-pyridin-3-yl-thiazol-2-yl)-amine 
• 373359-47-8 2-dibenzylamino-1-pyridin-3-yl-ethanone 
• 515179-33-6 (S)-2-chloro-1-(pyridin-3-yl)ethanol 
• 173901-03-6 (R)-2-chloro-1-(3-pyridyl)-ethanol 
• 373359-48-9 2-dibenzylamino-1-pyridin-3-yl-ethanol 

Relevant articles and documents

Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships

Dichloroacetophenone is a pyruvate dehydrogenase kinase 1 (PDK1) inhibitor with suboptimal kinase selectivity. Herein, we report the synthesis and biological evaluation of a series of novel dichloroacetophenones. Structure-activity relationship analyses (SARs) enabled us to identify three potent compounds, namely 54, 55, and 64, which inhibited PDK1 function, activated pyruvate dehydrogenase complex, and reduced the proliferation of NCI-H1975 cells. Mitochondrial bioenergetics assay suggested that 54, 55, and 64 enhanced the oxidative phosphorylation in cancer cells, which might contribute to the observed anti-proliferation effects. Collectively, these results suggested that 54, 55, and 64 could be promising compounds for the development of potent PDK1 inhibitors.