55510-25-3

Basic information

• Product Name: 3-methylbenzene-1-sulfonohydrazide
• Synonyms: 3-methylbenzene-1-sulfonohydrazide;3-Methylbenzene-1-sulphonohydrazide
• CAS NO: 55510-25-3
• Molecular Formula: C₇H₁₀N₂O₂S
• Molecular Weight: 186.23
• Mol File: 55510-25-3.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-methylbenzene-1-sulfonohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methylbenzene-1-sulfonohydrazide(55510-25-3)
• EPA Substance Registry System: 3-methylbenzene-1-sulfonohydrazide(55510-25-3)

Safety Data

• Hazardous Substances Data: 55510-25-3(Hazardous Substances Data)

Upstream product

• 1899-93-0 3-methylphenylsulfonyl chloride 

Downstream Products

• 1257390-76-3 1,3,7-trimethyl-8-(3-tolyl)-xanthine 
• 14625-58-2 2-(3-methylphenyl)benzoxazole 
• 102611-24-5 4-(3-methylphenyl)butan-2-one 
• 95465-70-6 1-phenyl-3-(3-methylphenyl)-1-propananone 
• 612-75-9 3,3'-dimethyl-biphenyl 
• 1394827-30-5 3-m-tolylindolizine-1-carbonitrile 
• 585-74-0 3-Methylacetophenone 
• 643-65-2 3-methyl benzophenone 
• 643-93-6 3-methylbiphenyl 

Relevant articles and documents

Dual Roles of Rongalite: Reductive Coupling Reaction to Construct Thiosulfonates Using Sulfonyl Hydrazides

A tunable and practical transformation of structurally diverse sulfonyl hydrazides into thiosulfonates in the presence of Rongalite (NaHSO 2·CH 2O) was developed. Transition-metal-free conditions, operational simplicity, and readily available reagents are the striking features of this protocol. It is the first example for the synthesis of thiosulfonates using sulfonyl hydrazides with the assistance of reductant. Additionally, the mechanistic studies revealed that this transformation probably undergoes via a reducing-coupling pathway.

Electrochemical Annulation-Iodosulfonylation of 1,5-Enyne-containing para-Quinone Methides (p-QMs) to Access (E)-Spiroindenes

A new electrochemical three-component annulation-iodosulfonylation of 1,5-enyne-containing para-quinone methides (p-QMs) has been established by using available arylsulfonyl hydrazides and potassium iodide under environmentally benign conditions. The electrosynthesis offers sustainable and efficient access to construct spirocyclohexadienone-containing (E)-indenes without any additional catalyst or oxidant through a sulfonyl-radical-triggered 1,6-addition and an I+-mediated ipso-cyclization cascade. Notably, potassium iodide plays the triple role of an electrolyte, a redox catalyst, as well as an iodination reagent.

Palladium-Catalyzed Regio- and Stereoselective Sulfonylation of Aryl Propiolates with Sulfonyl Hydrazides: Access to (E)-β-Aryl Sulfonyl Acrylates

An efficient method for the synthesis of (E)-β-aryl sulfonyl acrylates has been reported. This palladium-catalyzed approach showed excellent regio- and stereoselectivity in the sulfonylation of aryl propiolates with sulfonyl hydrazides. Through this approach, a wide range of (E)-β-aryl sulfonyl acrylates were obtained in moderate to high yields. (Figure presented.).