5552-44-3Relevant articles and documents
6-(4-Phenyl-benzyloxy-methyl) guvacine. Synthesis, GABA uptake inhibitor and muscarinic properties
Bisel, Philippe,Gies, Jean Pierre,Schlewer, Gilbert,Wermuth, Camille G.
, p. 3025 - 3028 (1996)
6-(4-Phenyl-benzyloxy-methyl) guvacine was synthesized. Surprisingly the compound was devoid of the γ-aminobutyric acid (GABA) uptake inhibitory activity of its parent compound guvacine, but instead showed affinities for the muscarinic M1 and M2 receptors.
PHARMACEUTICAL COMPOUNDS
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Page/Page column 116-117, (2021/04/02)
The invention provides a composition of matter which: ? (i) consists of at least 90 % by weight of an atropisomer (2A) and 0-10 % by weight of an atropisomer of formula (2B); or ? (ii) consists of at least 90 % by weight of an atropisomer (2B) and 0-10 %
PROCESS FOR THE PREPARATION OF 2,4- OR 2,5-PYRIDINEDICARBOXYLIC ACID AND COPOLYMERS DERIVED THEREFROM
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Paragraph 0200-0201, (2018/06/09)
The present invention relates to processes for the formation of pyridinedicarboxylic acid (PDCA), in particular, 2,4-pyridinedicarboxylic acid (2,4-PDCA) and 2,5-pyridinedicarboxylic acid (2,5-PDCA), and mono- and diester derivatives thereof, from 3,4-dihydroxybenzoic acid, via a biocatalytic reaction using, for example, a protocatechuate dioxygenase such as protocatechuate 4,5-dioxygenase or protocatechuate 2,3-dioxygenase, and a nitrogen source. The invention also relates to copolymers that comprise the pyridinedicarboxylic acid monomers and derivatives thereof, processes for the formation of the copolymers and uses for the copolymers.
A Ca2+-, Mg2+-, and Zn2+-Based Dendritic Contractile Nanodevice with Two pH-Dependent Motional Functions
Stadler, Adrian-Mihail,Karmazin, Lydia,Bailly, Corinne
supporting information, p. 14570 - 14574 (2016/01/25)
A contractile dendritic motional device is reported where metal ions with biological importance - Ca2+ (the main regulatory and signaling species of the natural muscles), Mg2+, and Zn2+ - initiate two kinds of motional functions. The first motional function is the metal-ion-induced contraction of a linear strand into a Z-shaped dinuclear complex, and the second one is the change of the height of Z-shaped complexes via transmetalation. By means of the pH-dependent counterligand tren, the two motional features of the machine can depend on alternate additions of acid and base. An optical response is associated with the conversion of the linear form (which is yellow) into the metalated Z-shaped one (which is red).