55580-07-9

Basic information

• Product Name: 4-(4-BROMO-PHENOXY)-BUTYRIC ACID
• Synonyms: 4-(p-BroMophenoxy)buttersaeure;4-(4-Bromophenoxy)
• CAS NO: 55580-07-9
• Molecular Formula: C₁₀H₁₁BrO₃
• Molecular Weight: 259.1
• Mol File: 55580-07-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 403.6°Cat760mmHg
• Flash Point: 197.9°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 3.07E-07mmHg at 25°C
• Refractive Index: 1.558
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-(4-BROMO-PHENOXY)-BUTYRIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-BROMO-PHENOXY)-BUTYRIC ACID(55580-07-9)
• EPA Substance Registry System: 4-(4-BROMO-PHENOXY)-BUTYRIC ACID(55580-07-9)

Safety Data

• Hazardous Substances Data: 55580-07-9(Hazardous Substances Data)

Usage

General Description

4-(4-Bromo-phenoxy)-butyric acid is a chemical compound with the molecular formula C10H11BrO3. It is a derivative of butyric acid and contains a bromo-substituted phenoxy group. 4-(4-BROMO-PHENOXY)-BUTYRIC ACID is commonly used in agrochemicals as a plant growth regulator, promoting root growth and increasing yield in various crops. It acts as a systemic fungicide and is effective against a wide range of plant pathogens. Additionally, 4-(4-Bromo-phenoxy)-butyric acid has potential applications in the field of medicine, specifically in the treatment of certain types of cancer. Its chemical structure and properties make it a versatile compound with promising uses in agriculture and medicine.

InChI:InChI=1/C10H11BrO3/c11-8-3-5-9(6-4-8)14-7-1-2-10(12)13/h3-6H,1-2,7H2,(H,12,13)

Upstream product

• 157245-87-9 4-(4-bromophenoxy)butyric acid ethyl ester 
• 106-41-2 4-bromo-phenol 

Downstream Products

• 55580-08-0 7-bromo-3,4-dihydrobenzo[b]oxepin-5(2H)-one 
• 127556-89-2 4-(4-Bromo-phenoxy)-butyric acid 4-bromo-phenyl ester 
• 229006-94-4 7-(4-methylphenyl)-2,3,4,5-tetrahydro-1-benzooxepin-5-one 
• 229006-96-6 7-(4-methylphenyl)-2,3-dihydro-1-benzooxepine-4-carboxylic acid 
• 229005-67-8 N-(4-((N-3-hydroxypropyl-N-methyl)aminomethyl)phenyl)-7-(4-methylphenyl)-2,3-dihydro-1-benzoxepine-4-carboxamide 
• 229004-30-2 7-(4-methylphenyl)-N-(4-(piperidinomethyl)phenyl)-2,3-dihydro-1-benzoxepine-4-carboxamide 
• 229005-55-4 N-(4-((N-tetrahydrothiopyran-4-yl-N-methyl)amino-methyl)phenyl)-7-(4-methylphenyl)-2,3-dihydro-1-benzoxepine-4-carboxamide 
• 229004-34-6 N-(4-(2-piperidinoethyl)phenyl)-7-(4-methylphenyl)-2,3-dihydro-1-benzoxepine-4-carboxamide 
• 229005-64-5 N-[4-[N-(4-oxycyclohexyl)-N-methylaminomethyl]phenyl]-7-(4-methylphenyl)-2,3-dihydro-1-benzoxepine-4-carboxamide 
• 229005-63-4 N-(4-((N-(4,4-ethylenedioxycyclohexyl)-N-methyl)aminomethyl)phenyl)-7-(4-methylphenyl)-2,3-dihydro-1-benzoxepine-4-carboxamide 
• 943739-77-3 4-(4-boronophenoxy)butyric acid 
• 943739-78-4 4-(3-benzyloxycarbonylpropoxy)phenylboronic acid 
• 943739-80-8 4-{4-[(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)carboxymethyl]phenoxy}butyric acid benzyl ester 
• 943739-82-0 4-{4-[(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-(3-nitrobenzylcarbamoyl)methyl]phenoxy}3-butyric acid benzyl ester 

Relevant articles and documents

Design, synthesis, and biological evaluation of 3-amino-2-oxazolidinone derivatives as potent quorum-sensing inhibitors of Pseudomonas aeruginosa PAO1

Due to the increasing resistance of Pseudomonas aeruginosa to most clinically relevant antimicrobials, it is challenging to treat bacterial infection with traditional antibiotics. Quorum sensing can regulate the production of biofilms and virulence factors which are closely related to bacterial resistance. Previously we synthesized a series of oxazolidinone compounds targeting the quorum-sensing transcriptional regulatory protein CviR and ZS-12 showed good activity against Chromobacterium violaceum CV026 quorum-sensing. In this study, eighteen 3-amino-2-oxazolidinone compounds were designed and synthesized using ZS-12 as the lead compound. We initially evaluated the inhibitory activities of novel oxazolidinone compounds against QS using C. violaceum CV026 as a reporter strain. Thirteen compounds showed good activities (IC50 range 3.69–63.58 μM) and YXL-13 inhibition was the most significant (IC50 = 3.686 ± 0.5790 μM) against biofilm formation and virulence factors determination of P. aeruginosa PAO1. In vitro, YXL-13 significantly inhibited the formation of PAO1 biofilm (range 42.98%–17.67%), the production of virulence factors (pyocyanin, elastase, rhamnolipid, and protease), and bacterial motility. Moreover, the combination of YXL-13 with an antibiotic (meropenem trihydrate) could significantly improve the antibiotic susceptibility of biofilm P. aeruginosa PAO1 cells. In vivo, YXL-13 significantly prolonged the lifespan of wildtype Caenorhabditis elegans N2 infected by P. aeruginosa PAO1. In conclusion, YXL-13 is a candidate agent for antibiotic-resistant P. aeruginosa PAO1and provides a method for finding new antibacterial drugs.

SUBSTITUTED POLYCYCLIC ANTIBACTERIAL COMPOUNDS

The present description relates to substituted polycyclic compounds of Formula (I), Formula (II) or Formula (III): wherein the dashed line represents an optional double bond and Rl, R2, R4, R5, R7, X and Z are as defined herein, and forms and compositions thereof, and also relates to uses of a compound of Formula (I), Formula (II) or Formula (III) or a form thereof and methods for treating or ameliorating Neisseria gonorrhoeae (N. gonorrhoeae) in a subject in need thereof comprising, administering an effective amount of the compound to the subject.

Potent inhibitors of LpxC for the treatment of gram-negative infections

In this paper, we present the synthesis and SAR as well as selectivity, pharmacokinetic, and infection model data for representative analogues of a novel series of potent antibacterial LpxC inhibitors represented by hydroxamic acid 1a.