55589-21-4

Basic information

• Product Name: 2-hydroxy-2,3-dihydro-1H-indene-2-carbonitrile
• Synonyms: 2-Hydroxy-2-indanecarbonitrile
• CAS NO: 55589-21-4
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.1846
• Mol File: 55589-21-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 350.5°C at 760 mmHg
• Flash Point: 165.8°C
• Density: 1.23g/cm³
• Vapor Pressure: 1.63E-05mmHg at 25°C
• Refractive Index: 1.613
• CAS DataBase Reference: 2-hydroxy-2,3-dihydro-1H-indene-2-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-2,3-dihydro-1H-indene-2-carbonitrile(55589-21-4)
• EPA Substance Registry System: 2-hydroxy-2,3-dihydro-1H-indene-2-carbonitrile(55589-21-4)

Safety Data

• Hazardous Substances Data: 55589-21-4(Hazardous Substances Data)

Upstream product

• 615-13-4 2-indanone 
• 151-50-8 potassium cyanide 
• 67851-69-8 Sodium; 2-hydroxy-indan-2-sulfonate 

Downstream Products

• 530-93-8 1,2,3,4-tetrahydronaphthalen-2-one 
• 86344-80-1 3'-(N-benzyl-N-phenylaminomethyl)indane-3-spiro-5'-oxazolidine-2',4'-dione 
• 86344-77-6 3'-<(4-benzhydrylpiperazino)methyl>indane-2-spiro-5'-oxazolidine-2',4'-dione 
• 106167-47-9 1H-indene-2-carboxylic acid ethyl ester 

Relevant articles and documents

Safe execution of a large-scale ozonolysis: Preparation of the bisulfite adduct of 2-hydroxyindan-2-carboxaldehyde and its utility in a reductive amination

Several routes to bisulfite adduct 2 were explored, the most efficient of which involved vinyl Grignard addition to 2-indanone followed by ozonolysis and workup with aqueous NaHSO3 to effect reduction and bisulfite formation in a single pot. The safety and calorimetry of this ozonolysis reaction was studied, and the safe scale-up to 3 kg of olefin is described. The utility of bisulfite adduct 2 as an aldehyde surrogate in a reductive amination reaction is also described.