556039-75-9Relevant articles and documents
New bis(pyridyl)methane derivatives from 4-hydroxy-2-pyridones: Synthesis and antitumoral activity
Cocco, Maria Teresa,Congiu, Cenzo,Onnis, Valentina
, p. 37 - 47 (2007/10/03)
Bis(pyridyl)methane derivatives 5-40 were obtained from the reaction of 4-hydroxy-2-pyridones 3 and 4 with aldehydes. Compounds 5-40 were evaluated for cytotoxic activity against a panel of 60 human cancer cell lines by the National Cancer Institute and some of them demonstrated inhibitory effects on the growth of a wide range of cancer cell lines generally at 10-5 M level and in some case at 10-7 M concentrations.