556112-19-7

Basic information

• Product Name: Benzene, 1,2-dichloro-3-ethynyl-
• Synonyms: Benzene, 1,2-dichloro-3-ethynyl-;1,2-Dichloro-3-ethynyl-benzene
• CAS NO: 556112-19-7
• Molecular Formula: C₈H₄Cl₂
• Molecular Weight: 171.02336
• Mol File: 556112-19-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzene, 1,2-dichloro-3-ethynyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1,2-dichloro-3-ethynyl-(556112-19-7)
• EPA Substance Registry System: Benzene, 1,2-dichloro-3-ethynyl-(556112-19-7)

Safety Data

• Hazardous Substances Data: 556112-19-7(Hazardous Substances Data)

Usage

Description

Benzene, 1,2-dichloro-3-ethynyl-, also known as DCE, is a chemical compound with the molecular formula C8H4Cl2. It is a colorless liquid with a sweet odor and is insoluble in water.

Uses

Used in Industrial Applications:
Benzene, 1,2-dichloro-3-ethynylis used as a solvent for various industrial applications, including the production of adhesives, coatings, and cleaning agents.
Used in Pharmaceutical and Agrochemical Manufacturing:
Benzene, 1,2-dichloro-3-ethynylis used as an intermediate in the manufacturing of pharmaceuticals and agrochemicals.

Upstream product

• 1057096-65-7 [(2,3-dichlorophenyl)ethynyl](trimethyl)silane 
• 2401-21-0 1,2-Dichloro-3-iodobenzene 
• 56961-77-4 1-bromo-2,3-dichlorobenzene 

Downstream Products

• 936219-31-7 5-(2,3-dichlorophenyl)-1-(2,3-dihydro-1-benzofuran-7-ylmethyl)-1H-1,2,3-triazole 
• 1378976-06-7 4-(2,3-dichlorophenyl)-1H-1,2,3-triazole 

Relevant articles and documents

Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition

Indoleamine 2,3-dioxygenase 1 (IDO1) is an important therapeutic target for the treatment of diseases such as cancer that involve pathological immune escape. Starting from the scaffold of our previously discovered IDO1 inhibitor 4-phenyl-1,2,3-triazole, we used computational structure-based methods to design more potent ligands. This approach yielded highly efficient low molecular weight inhibitors, the most active being of nanomolar potency both in an enzymatic and in a cellular assay, while showing no cellular toxicity and a high selectivity for IDO1 over tryptophan 2,3-dioxygenase (TDO). A quantitative structure-activity relationship based on the electrostatic ligand-protein interactions in the docked binding modes and on the quantum chemically derived charges of the triazole ring demonstrated a good explanatory power for the observed activities.

P2X7 receptor antagonists and methods of use

The invention is directed to compounds that are P2X7 antagonist and have the formula (I) or (II) or a pharmaceutically acceptable salt, prodrug, salt of a prodrug or a combination thereof, wherein R1, R2, and R3 /sub