55625-40-6Relevant articles and documents
Quinoline substituted chalcone compound as well as preparation method and application thereof
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Paragraph 0026; 0059; 0061; 0062, (2019/03/29)
The invention discloses a novel quinoline substituted chalcone compound as well as pharmaceutically acceptable salts and a preparation method thereof. The invention further discloses a pharmaceuticalcomposition which comprises a therapeutically effective amount of the novel quinoline substituted chalcone compound and/or the pharmaceutically acceptable salts and a pharmaceutically acceptable carrier. The invention further discloses a tubulin inhibitor which comprises the novel quinoline substituted chalcone compound and/or the pharmaceutically acceptable salts. The invention further disclosesapplication of the novel quinoline substituted chalcone compound and/or the pharmaceutically acceptable salts in preparing drugs for treating but not limited to colon cancer, leukemia, liver cancer, breast cancer and other diseases. The compound in the application shows excellent anti-tumor activity, and has more stable metabolic properties and better druggability prospect.
Studies on the N-oxides of π-deficient N-heteroaromatics. XXIV. A novel synthesis of substituted indoles by photochemical ring contraction of 3,1-benzoxazepines
Kaneko,Fujii,Kawai,et al.
, p. 1157 - 1171 (2007/10/02)
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