5563-21-3

Basic information

• Product Name: 6-methoxy-3-methyl-3,4-dihydronaphthalen-1(2H)-one
• Synonyms: 6-methoxy-3-methyl-3,4-dihydronaphthalen-1(2H)-one;1(2H)-NAPHTHALENONE, 3,4-DIHYDRO-6-METHOXY-3-METHYL-
• CAS NO: 5563-21-3
• Molecular Formula: C₁₂H₁₄O₂
• Molecular Weight: 190.23836
• Mol File: 5563-21-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-methoxy-3-methyl-3,4-dihydronaphthalen-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methoxy-3-methyl-3,4-dihydronaphthalen-1(2H)-one(5563-21-3)
• EPA Substance Registry System: 6-methoxy-3-methyl-3,4-dihydronaphthalen-1(2H)-one(5563-21-3)

Safety Data

• Hazardous Substances Data: 5563-21-3(Hazardous Substances Data)

Upstream product

• 623-70-1 ethyl (E)-crotonate 
• 54961-40-9 4-(3-methoxyphenyl)-3-methylbutanoic acid 
• 93570-81-1 ethyl 4-(3-methoxyphenyl)-3-methylbutanoate 
• 3027-13-2 1-(3-methoxyphenyl)propan-2-one 

Downstream Products

• 82524-98-9 4-(6-Methoxy-3-methyl-3,4-dihydro-naphthalen-1-yl)-phenol 
• 1354491-39-6 4-(4-chlorophenyl)-7-methoxy-2-methyl-1,2-dihydronaphthalene 
• 1354491-40-9 3-bromo-4-(4-chlorophenyl)-7-methoxy-2-methyl-1,2-dihydronaphthalene 
• 1354491-41-0 2-bromo-1-(4-chlorophenyl)-6-methoxy-3-methylnaphthalene 
• 1354491-42-1 6-bromo-5-(4-chlorophenyl)-7-methylnaphthalen-2-ol 
• 1354491-44-3 ethyl 2-(1-(4-chlorophenyl)-3-methyl-6-(triisopropyl-silyloxy)naphthalen-2-yl)-2-oxoacetate 
• 1354491-45-4 ethyl 2-(1-(4-chlorophenyl)-3-methyl-6-(trifluoromethylsulfonyloxy)naphthalen-2-yl)-2-oxoacetate 
• 1354491-46-5 (S)-ethyl 2-(1-(4-chlorophenyl)-3-methyl-6-(trifluoromethylsulfonyloxy)naphthalen-2-yl)-2-hydroxyacetate 
• 1354491-47-6 (S)-ethyl 2-tert-butoxy-2-(1-(4-chlorophenyl)-3-methyl-6-(trifluoromethylsulfonyloxy)naphthalen-2-yl)acetate 
• 1354491-48-7 (S)-ethyl 2-tert-butoxy-2-(1-(4-chlorophenyl)-3-methyl-6-(pyridin-4-yl)naphthalen-2-yl)acetate 
• 1354491-49-8 (S)-ethyl 2-tert-butoxy-2-(1-(4-chlorophenyl)-3-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-2-yl)acetate 
• 1354491-50-1 (S)-ethyl 2-tert-butoxy-2-(1-(4-chlorophenyl)-3-methyl-6-(pyrimidin-2-yl)naphthalen-2-yl)acetate 
• 1354491-51-2 (S)-ethyl 2-tert-butoxy-2-(1-(4-chlorophenyl)-3-methyl-6-(pyridin-2-yl)naphthalen-2-yl)acetate 
• 1354491-43-2 (6-bromo-5-(4-chlorophenyl)-7-methylnaphthalen-2-yloxy)triisopropylsilane 

Relevant articles and documents

DIHYDRONAPHTHALENE DERIVATIVE

A compound shown by general formula (I) (in the formula, all of the symbols are as defined in the specification) has selective S1P5 receptor agonist activity due to having a linker from a phenyl group to a cyclic substituent in a dihydronaphthalene skelet

Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: Influence of heteroaryl derivatization on potency and selectivity

Recently, we reported on the development of potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis. A major drawback of these nonsteroidal compounds was a strong inhibition of the hepatic drug-metabolizing enzyme CYP1A2. In the present study, we examined the influence of substituents in the heterocycle of lead structures with a naphthalene molecular scaffold to overcome this unwanted side effect. With respect to CYP11B2 inhibition, some substituents induced a dramatic increase in inhibitory potency. The methoxyalkyl derivatives 22 and 26 are the most potent CYP11B2 inhibitors up to now (IC50 = 0.2 nM). Most compounds also clearly discriminated between CYP11B2 and CYP11B1, and the CYP1A2 potency significantly decreased in some cases (e.g., isoquinoline derivative 30 displayed only 6% CYP1A2 inhibition at 2 μM concentration). Furthermore, isoquinoline derivative 28 proved to be capable of passing the gastrointestinal tract and reached the general circulation after peroral administration to male Wistar rats.

1-AMINOMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENES

Compounds of the formula STR1 and pharmaceutically acceptable salt thereof, wherein R 2 is selected from hydroxy and lower alkoxy, R 5 is lower alkyl, and R 11 and R 12 are independently selected from hydrogen, halo, hydroxy, methoxy, and lower alkyl, are selective . alpha.. sub.2 adrenergic receptor antagonists useful in the treatment of glaucoma.