55653-99-1

Basic information

• Product Name: 1-ethyl-2,3-diphenyl-1H-indole
• Synonyms: 1-ethyl-2,3-diphenyl-1H-indole
• CAS NO: 55653-99-1
• Molecular Weight: 297.4
• Mol File: 55653-99-1.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 1-ethyl-2,3-diphenyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ethyl-2,3-diphenyl-1H-indole(55653-99-1)
• EPA Substance Registry System: 1-ethyl-2,3-diphenyl-1H-indole(55653-99-1)

Safety Data

• Hazardous Substances Data: 55653-99-1(Hazardous Substances Data)

Upstream product

• 612-64-6 N-ethyl-N-nitrosoaniline 
• 886-38-4 diphenylcyclopropenone 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 62-53-3 aniline 
• 74-96-4 ethyl bromide 
• 3469-20-3 2,3-diphenyl-1H-indole 
• 825-19-4 N-methyl-N-ethylaniline N-oxide 
• 501-65-5 diphenyl acetylene 
• 826-42-6 N,N-diethylaniline N-oxide 
• 1610870-77-3 1-ethyl-2-isobutylidene-1-phenylhydrazine 
• 615-43-0 2-iodophenylamine 
• 110-89-4 piperidine 
• 1529541-83-0 2-iodo-N,N-diethylaniline 
• 103-69-5 N-ethyl-N-phenylamine 

Relevant articles and documents

One-Pot Tandem ortho-Naphthoquinone-Catalyzed Aerobic Nitrosation of N-Alkylanilines and Rh(III)-Catalyzed C-H Functionalization Sequence to Indole and Aniline Derivatives

The nitroso group served as a traceless directing group for the C-H functionalization of N-alkylanilines, ultimately removed after functioning either as an internal oxidant or under subsequent reducing conditions. The unique ability of o-NQ catalysts to aerobically oxidize the N-alkylanilines without using solvents and stoichiometric amounts of oxidants has rendered the new opportunity to develop the telescoped catalyst systems without a need for directly handling the hazardous N-nitroso compounds.

Indole derivative and its preparation method (by machine translation)

The present invention provides indole derivative and its preparation method, comprises the following steps: a compound represented by formula I, additive and solvent mixed, in nitrogen or argon and visible light illumination under the conditions of reaction, to obtain the indole derivatives. In a nitrogen or argon atmosphere, through visible light radiation excitation I shown in the polyurea compound of carbon oxygen key, then the occurrence of [1, 6] - H migration, eventually through the intramolecular radical coupling and dehydration reaction for the synthesis of indole derivatives, the whole process needs no photocatalyst participation, the operation is simple, mild condition, high yield, accords with the atom economic and environmental protection, for the industrial preparation of indole derivatives having a high reference value. (by machine translation)

Rhodium(iii)-catalyzed indole synthesis at room temperature using the transient oxidizing directing group strategy

Rh-catalyzed reactions of N-alkyl anilines with internal alkynes at room temperature have been developed using an in situ generated N-nitroso group as a transient oxidizing directing group. Due to mild reaction conditions, this method enabled synthesis of a broad range of N-alkyl indoles, including even two indole-based medicinal compounds. Our work disclosed the feasibility of the transient oxidizing directing group strategy in C-H functionalization reactions, which possesses the potential to enhance overall step-economy and impart new reactivity patterns to substrates.