556801-15-1

Basic information

• Product Name: N-[[(5S)-3-[4-(4-Morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]Methyl]acetaMide
• Synonyms: Defluoro Linezolid;N-[[(5S)-3-[4-(4-Morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]Methyl]acetaMide;Linezolid Desfluoro Impurity;N-((3-(4-(4-Morpholinyl)phenyl)-2-oxo-5-oxazolidinyl)methyl) acetamide;Linezolid impurity D;linezolid Impurity H
• CAS NO: 556801-15-1
• Molecular Formula: C16H21N3O4
• Molecular Weight: 319.35564
• Product Categories: Aromatices;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 556801-15-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 581.5±45.0 °C(Predicted)
• Appearance: /
• Density: 1.253±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 15.53±0.46(Predicted)
• CAS DataBase Reference: N-[[(5S)-3-[4-(4-Morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]Methyl]acetaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[[(5S)-3-[4-(4-Morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]Methyl]acetaMide(556801-15-1)
• EPA Substance Registry System: N-[[(5S)-3-[4-(4-Morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]Methyl]acetaMide(556801-15-1)

Safety Data

• Hazardous Substances Data: 556801-15-1(Hazardous Substances Data)

Usage

Chemical Properties

White to Off-White Solid

Uses

Defluoro Linezolid is a defluorinated impurity of Linezolid (L466500).

Upstream product

• 108-24-7 acetic anhydride 
• 952288-54-9 (S)-5-Aminomethyl-3-(4-morpholin-4-yl-phenyl)-oxazolidin-2-one 
• 67-56-1 methanol 
• 165800-03-3 linezolid 
• 110-91-8 morpholine 
• 909570-02-1 N-[(3-(4-bromophenyl)-2-oxo-5-oxazolidinyl)methyl]-acetamide 

Relevant articles and documents

Photochemistry of oxazolidinone antibacterial drugs

The photochemistry of six N3-(3-fluoro-4-dialkylaminophenyl)-oxazolidinones known for their antimicrobial activity has been examined. All of these compounds are defluorinated in water (φdec ≈ 0.25) and in methanol (φdec ≈ 0.03), reas

ISOLATED DESFLUORO-LINEZOLID, PREPARATION THEREOF AND ITS USE AS A REFERENCE MARKER AND STANDARD

The present invention provides an isolated linezolid impurity, desfluoro linezolid, the preparation thereof and its use as a reference standard.