556826-36-9

Basic information

• Product Name: 4-Azulenepropanoic acid, 2-methyl-
• CAS NO: 556826-36-9
• Molecular Formula: C14H14O2
• Molecular Weight: 214.264
• Mol File: 556826-36-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Azulenepropanoic acid, 2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Azulenepropanoic acid, 2-methyl-(556826-36-9)
• EPA Substance Registry System: 4-Azulenepropanoic acid, 2-methyl-(556826-36-9)

Safety Data

• Hazardous Substances Data: 556826-36-9(Hazardous Substances Data)

Upstream product

• 769-86-8 2-methylazulene 

Relevant articles and documents

A practical approach for the preparation of monofunctional azulenyl squaraine dye

The synthesis of monofunctional azulenyl squaraine dye NIRQ700 is described. The essential azulene intermediate 3, 1-(methoxycarbonyl)-2-methylazulene, was achieved via [8+2] cycloaddition between lactone 2, 2H-3-methoxycarbonyl-cyclohepta[b]furan-2-one, and the in situ generated vinyl ethers under high temperature and pressure conditions. Methylation on the cycloheptatriene ring of 2-methyl azulene 6 via Meisenheimer-type intermediate following Schrott's method formed the carboxylic acid intermediate 9, 3-(2-methyl-azulen-4-yl)-propionic acid. Condensation of 9 with squaric acid provided the title compound NIRQ700 at moderate yields. The non-fluorescent squaraine dye NIRQ700 absorbed in a 600-700 nm range and potentially can be used to quench a number of available NIR fluorochromes in order to extend the spectrum of biological quenching assays.