557095-50-8

Basic information

• Product Name: Butanethioic acid, 2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-3-methyl-, S-(2-formyl-4-nitrophenyl) ester, (2S)-
• CAS NO: 557095-50-8
• Molecular Formula: C27H24N2O6S
• Molecular Weight: 504.563
• Mol File: 557095-50-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Butanethioic acid, 2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-3-methyl-, S-(2-formyl-4-nitrophenyl) ester, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanethioic acid, 2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-3-methyl-, S-(2-formyl-4-nitrophenyl) ester, (2S)-(557095-50-8)
• EPA Substance Registry System: Butanethioic acid, 2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-3-methyl-, S-(2-formyl-4-nitrophenyl) ester, (2S)-(557095-50-8)

Safety Data

• Hazardous Substances Data: 557095-50-8(Hazardous Substances Data)

Upstream product

• 103321-53-5 (S)-(9H-fluoren-9-yl)methyl 1-chloro-3-methyl-1-oxobutan-2-ylcarbamate 
• 6361-21-3 2-chloro-5-nitrobenzaldehyde 

Downstream Products

• 203636-24-2 Fmoc-Val-Aib-OBn 

Relevant articles and documents

Chemoselective peptide bond formation using formyl-substituted nitrophenylthio ester

A novel method for peptide bond formation utilizing amino acid 2-formyl-4-nitrophenylthio ester has been developed. The reaction can be performed in water-containing media and is compatible with various types of amino acid side-chain functional groups. Use of N-methylmaleinimide as an additive is essential for the reaction to proceed with high efficiency. It captures liberated formyl-substituted thiophenol through 1,4-addition followed by aldol cyclization.