5571-03-9

Basic information

• Product Name: 5-Pyrimidinecarboxylic acid, 2-methyl-, methyl ester (7CI,8CI,9CI)
• Synonyms: 5-Pyrimidinecarboxylic acid, 2-methyl-, methyl ester (7CI,8CI,9CI);5-PyriMidinecarboxylic acid, 2-Methyl-, Methyl ester
• CAS NO: 5571-03-9
• Molecular Formula: C7H8N2O2
• Molecular Weight: 152.15062
• Product Categories: PYRIMIDINE
• Mol File: 5571-03-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-Pyrimidinecarboxylic acid, 2-methyl-, methyl ester (7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinecarboxylic acid, 2-methyl-, methyl ester (7CI,8CI,9CI)(5571-03-9)
• EPA Substance Registry System: 5-Pyrimidinecarboxylic acid, 2-methyl-, methyl ester (7CI,8CI,9CI)(5571-03-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 5571-03-9(Hazardous Substances Data)

Usage

General Description

5-Pyrimidinecarboxylic acid, 2-methyl-, methyl ester (7CI,8CI,9CI) is a chemical compound with a complex molecular structure. It belongs to the group of pyrimidines, which are aromatic heterocyclic organic compounds similar to pyridine. This specific compound can be characterized by its methyl ester functional group, which replaces the hydroyxl group of carboxylic acids. Furthermore, it has two methyl groups attached to it; one at the pyrimidine ring and the other to a carboxylic acid group. The exact properties, uses, and safety measures of this chemical would depend on a more detailed study of its characteristics.

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Relevant articles and documents

Reaction Scope of Methyl 1,2,3-Triazine-5-carboxylate with Amidines and the Impact of C4/C6 Substitution

A comprehensive study of the reaction scope of methyl 1,2,3-triazine-5-carboxylate (3a) with alkyl and aryl amidines is disclosed, reacting at room temperature at remarkable rates (5 min, 0.1 M in CH3CN) nearly 10000-fold faster than that of unsubstituted 1,2,3-triazine and providing the product pyrimidines in high yields. C4 Methyl substitution of the 1,2,3-triazine (3b) had little effect on the rate of the reaction, whereas C4/C6 dimethyl substitution (3c) slowed the room-temperature reaction (24 h, 0.25 M) but displayed an unaltered scope, providing the product pyrimidines in similarly high yields. Measured second-order rate constants of the reaction of 3a-c, the corresponding nitriles 3e and 3f, and 1,2,3-triazine itself (3d) with benzamidine and substituted derivatives quantitated the remarkable reactivity of 3a and 3e, verified the inverse electron demand nature of the reaction (Hammett ρ = -1.50 for substituted amidines, ρ = +7.9 for 5-substituted 1,2,3-triazine), and provided a quantitative measure of the impact of 4-methyl and 4,6-dimethyl substitution on the reactivity of the methyl 1,2,3-triazine-5-carboxylate and 5-cyano-1,2,3-triazine core heterocycles.

P2X3 AND/OR P2X2/3 COMPOUNDS AND METHODS

The present application provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of formula (I), wherein R1-R4 are defined herein. In a further embodiment, these compounds are useful in method for regulating one or both of the P2X3 or P2X2/3 receptors. In another embodiment, these compounds are useful for treating pain in patients by administering one or more of the compounds to a patient.

PGD2 receptor antagonists for the treatment of inflammatory diseases

Disclosed herein are compounds represented by Structural Formula (I) and (I-A): Also disclosed is the use of such compounds for inhibiting the G-protein coupled receptor referred to as chemoattractant receptor-homologous molecule expressed on Th2, or simp