55739-20-3Relevant articles and documents
Total synthesis and anti-tubulin activity of epi-C3 analogues of cryptophycin-24
Buck, Suzanne B.,Huff, Jacquelyn K.,Himes, Richard H.,Georg, Gunda I.
, p. 3697 - 3699 (2007/10/03)
Epi-C3-cryptophycin-24, epi-C3-m-chlorobenzyl-cryptophycin-24, and the corresponding styrenes were synthesized and tested in vitro against the MCF-7 and multidrug-resistant MCF-7/ADR breast cancer cell lines and in an in vitro tubulin assembly assay. The results demonstrate that the S configuration at the C3 stereocenter is not required to induce potent cytotoxicity and the m-Cl substituent present on the C10 side chain did not induce any large change in activity.