5574-24-3 Usage
Description
Oxoglaucine is an alkaloid that can be isolated from Annona purpurea, a plant species known for its various bioactive compounds. It is characterized by the presence of four methoxyl groups in its molecular structure, which contribute to its unique properties and potential applications. Physiologically, oxoglaucine has demonstrated cytotoxic effects against 9-KB experimental tumors, indicating its potential as a bioactive compound with therapeutic applications.
Uses
Used in Pharmaceutical Industry:
Oxoglaucine is used as a cytotoxic agent for its potential anticancer properties. oxoglaucine's ability to exhibit cytotoxic effects against 9-KB experimental tumors suggests that it may have applications in the development of cancer treatments, particularly for targeting and eliminating cancer cells.
Used in Drug Discovery and Development:
Oxoglaucine's cytotoxic nature also makes it a valuable compound for drug discovery and development. Researchers can investigate its potential as a lead compound in the creation of new pharmaceuticals targeting various diseases, including cancer. Further studies on its mechanism of action, bioavailability, and safety profile would be necessary to advance its use in this field.
References
Sonnet, Jacobson,J. Pharm. Sci., 60, 1254 (1971)
Check Digit Verification of cas no
The CAS Registry Mumber 5574-24-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,5,7 and 4 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 5574-24:
(6*5)+(5*5)+(4*7)+(3*4)+(2*2)+(1*4)=103
103 % 10 = 3
So 5574-24-3 is a valid CAS Registry Number.
InChI:InChI=1/C20H17NO5/c1-23-13-8-11-12(9-14(13)24-2)19(22)18-16-10(5-6-21-18)7-15(25-3)20(26-4)17(11)16/h5-9H,1-4H3
5574-24-3Relevant articles and documents
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Cohen et al.
, p. 4143 (1961)
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A divergent approach to benzylisoquinoline-type and oxoaporphine alkaloids via regioselective direct ring metalation of alkoxy isoquinolines
Melzer, Benedikt,Bracher, Franz
, p. 7664 - 7672 (2015/07/15)
Methoxy- and benzyloxy-substituted isoquinolines are regioselectively metalated at C-1 with the Knochel-Hauser base, subsequent trapping with aromatic aldehydes gives aryl(isoquinolin-1-yl)carbinols as building blocks for divergent syntheses of different types of benzylisoquinoline alkaloids. Photochemical cyclization of ortho-bromo analogues under reductive conditions gives oxoaporphine alkaloids. Nine benzylisoquinoline alkaloids and two oxoaporphine alkaloids were obtained in two or three steps from appropriate isoquinolines.
Manganese(III) acetate mediated oxidation of aporphines: a convenient and useful synthesis of oxoaporphines
Singh, Om V.,Huang, Wei-Jan,Chen, Chung-Hsiung,Lee, Shoei-Sheng
, p. 8166 - 8169 (2008/03/13)
Manganese(III) acetate mediated oxidation of aporphines to oxoaporphines is described. The developed methodology was conveniently applied for the synthesis of naturally occurring oxoaporphine alkaloids, oxoglaucine, and atheroline, starting from commercially available boldine.
