5581-55-5

Basic information

• Product Name: METHYL-D3-AMINE
• Synonyms: Methan-d3-amine;METHYLAMINE (D3);METHYL-D3-AMINE;METHYL-D3-AMINE, 99 ATOM % D;(2H3)Methylamine;(α,α,α-2H3)Methanamine;BAVYZALUXZFZLV-FIBGUPNXSA-N
• CAS NO: 5581-55-5
• Molecular Formula: CH₅N
• Molecular Weight: 34.08
• Product Categories: Alphabetical Listings;Chemical Synthesis;Compressed and Liquefied GasesStable Isotopes;GasesStable Isotopes;M;Synthetic Reagents
• Mol File: 5581-55-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: −93 °C(lit.)
• Boiling Point: −6.3 °C(lit.)
• Appearance: /
• Density: 0.699g/cm³
• Vapor Density: 1.08 (20 °C, vs air)
• Vapor Pressure: 27 psi ( 20 °C)
• Refractive Index: 1.34
• CAS DataBase Reference: METHYL-D3-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL-D3-AMINE(5581-55-5)
• EPA Substance Registry System: METHYL-D3-AMINE(5581-55-5)

Safety Data

• Hazard Codes: F,T,F+
• Statements: 11-23-34-12
• Safety Statements: 16-26-36/37/39-45
• RIDADR: UN 1061 2.1
• WGK Germany: 3
• Hazardous Substances Data: 5581-55-5(Hazardous Substances Data)

Usage

Uses

A dueterated isotope of Methylamine (M285560) a common chemical reagent used in the synthesis of 2-aminoquinolines as potent and selective inhibitors of neuronal nitric oxide synthase for neurodegenrative disorders.

InChI:InChI=1/CH5N/c1-2/h2H2,1H3/i1D3

Upstream product

• 2290-65-5 trimethylsilyl isothiocyanate 

Downstream Products

• 68426-45-9 N-nitroso-N-trideuteriomethyl-urea 
• 3767-37-1 pentadeuterio-methylamine 
• 1089675-55-7 C₁₁H₁₁⁽²⁾H₆NO₃ 
• 1189858-48-7 4-chloropyridinyl-2-(N-1',1',1'-trideuteromethylcarboxamide) 
• 1609393-89-6 4,6-dichloro-N-trideuteromethylpyridazine-3 -carboxamide 

Relevant articles and documents

β-deuterium Isotope Effects on Amine Basicity, Inductive and Stereochemical

Secondary β deuterium isotope effects on acidity constants of ammonium ions are measured using a remarkably precise NMR titration method. Deuteration is found to increase the basicity of methylamine, dimethylamine, benzylamine, and N,N-dimethylaniline. The effect is attributed to a lowered zero-point energy of a CH bond adjacent to an amine nitrogen. The method permits a determination of the stereochemical dependence of the isotope effect in a locked piperidine, and it is found that deuteration is more effective when antiperiplanar to a lone pair. The values are consistent with a cos2 dependence on dihedral angle, with no detectable angle-independent inductive effect. Copyright