55831-54-4

Basic information

• Product Name: isopropenyl (-)-(1R,2S,5R)-menthol ether
• Synonyms: isopropenyl (-)-(1R,2S,5R)-menthol ether
• CAS NO: 55831-54-4
• Molecular Weight: 196.333
• Mol File: 55831-54-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: isopropenyl (-)-(1R,2S,5R)-menthol ether(CAS DataBase Reference)
• NIST Chemistry Reference: isopropenyl (-)-(1R,2S,5R)-menthol ether(55831-54-4)
• EPA Substance Registry System: isopropenyl (-)-(1R,2S,5R)-menthol ether(55831-54-4)

Safety Data

• Hazardous Substances Data: 55831-54-4(Hazardous Substances Data)

Upstream product

• 27607-77-8 trimethylsilyl trifluoromethanesulfonate 
• 167702-76-3 (1S,2R,4R)-1-Isopropyl-2-(1-methoxy-1-methyl-ethoxy)-4-methyl-cyclohexane 
• 116-11-0 2-Methoxypropene 
• 2216-51-5 (-)-menthol 

Downstream Products

• 81-82-3 (R)-3-(1-(4-chlorophenyl)-3-oxobutyl)-4-hydroxy-2H-chromen-2-one 
• 81-82-3 (S)-3-(1-(4-chlorophenyl)-3-oxobutyl)-4-hydroxy-2H-chromen-2-one 

Relevant articles and documents

Modular ketal-linked prodrugs and biomaterials enabled by organocatalytic transisopropenylation of alcohols

Isopropenyl ethers are critical intermediates for accessing medicinally valuable ketal-based prodrugs and biomaterials, but traditional approaches for the synthesis of isopropenyl ethers suffer from poor functional group compatibility and harsh reaction conditions. Here, we develop an organocatalytic transisopropenylation approach to solve these challenges, enabling the synthesis of isopropenyl ethers from various hydroxyl-group-containing small-molecule drugs, polymers, and functional building blocks. The method provides a straightforward and versatile synthesis of isopropenyl ethers, features excellent tolerance of diverse functional groups, applies to a wide range of substrates, and allows scalable synthesis. The development of this organocatalytic transisopropenylation approach enables access to modular preparation of various acid-sensitive ketal-linked prodrugs and functionalized ketalated biomaterials. We expect our syntheses and transformations of isopropenyl ethers will find utility in several diverse fields, including medicinal chemistry, drug delivery, and biomaterials.