5584-18-9

Basic information

• Product Name: Picolinic acid, 6-amino-, hydrazide (7CI,8CI)
• Synonyms: Picolinic acid, 6-amino-, hydrazide (7CI,8CI);6-Amino-2-Pyridinecarbohydrazide;6-aminopicolinohydrazide
• CAS NO: 5584-18-9
• Molecular Formula: C₆H₈N₄O
• Molecular Weight: 152.15
• Mol File: 5584-18-9.mol
• Article Data: 25

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Picolinic acid, 6-amino-, hydrazide (7CI,8CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Picolinic acid, 6-amino-, hydrazide (7CI,8CI)(5584-18-9)
• EPA Substance Registry System: Picolinic acid, 6-amino-, hydrazide (7CI,8CI)(5584-18-9)

Safety Data

• Hazardous Substances Data: 5584-18-9(Hazardous Substances Data)

Usage

General Description

Picolinic acid, 6-amino-, hydrazide (7CI,8CI) is a chemical compound with the molecular formula C6H8N4O2. It is also known as 6-amino-2-picolinic hydrazide. Picolinic acid, 6-amino-, hydrazide (7CI,8CI) is commonly used as a ligand in the synthesis of metal complexes for various applications in coordination chemistry. It has also been studied for its potential use as a chelating agent in the treatment of metal toxicity. Additionally, picolinic acid, 6-amino-, hydrazide (7CI,8CI) has been investigated for its antimicrobial properties and its potential use in pharmaceuticals. Overall, this chemical compound has a variety of potential applications in different fields such as medicine, chemistry, and environmental science.

Upstream product

• 36052-26-3 methyl 6-aminopyridine-2-carboxylate 

Downstream Products

• 1448428-05-4 5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide 
• 1448428-04-3 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-{6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-yl}benzamide 

Relevant articles and documents

Discovery of CNS-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors

Apoptosis signal-regulating kinase 1 (ASK1) is a key mediator in the apoptotic and inflammatory cellular stress response. To investigate the therapeutic value of modulating this pathway in neurological disease, we have completed medicinal chemistry studie

Structure-based discovery of 1H-indole-2-carboxamide derivatives as potent ASK1 inhibitors for potential treatment of ulcerative colitis

Apoptosis signal-regulating kinase 1 (ASK1), a member of the mitogen-activated protein kinase (MAPK) family, is implicated in many human diseases. Here, we describe the structural optimization of hit compound 7 and conduct further structure-activity relationship (SAR) studies that result in the development of compound 19 with a novel indole-2-carboxamide hinge scaffold. Compound 19 displays potent anti-ASK1 kinase activity and stronger inhibitory effect on ASK1 in AP1-HEK293 cells than previously described ASK1 inhibitor GS-4997. Besides improved in vitro activity, compound 19 also exhibits an appropriate in vivo PK profile. In a dextran sulfate sodium (DSS)-induced mouse model of ulcerative colitis (UC), compound 19 shows significant anti-UC efficacy and markedly attenuates DSS-induced body weight loss, colonic shortening, elevation in disease activity index (DAI) and inflammatory cell infiltration in colon tissues. Mechanistically, compound 19 represses the phosphorylation of ASK1-p38/JNK signaling pathways and suppresses the overexpression of inflammatory cytokines. Together, these findings suggest that ASK1 inhibitors can potentially be used as a therapeutic strategy for UC.

ASK1 INHIBITING AGENTS

Provided are compounds of Formula (I): Formula (I), including compounds of Formulas (II), (III), (IV), (V) and (VI), wherein X, R1, R2, R3, R4 and n are as defined herein,and pharmaceutically acceptable salts thereof, and methods for their use and production. These compounds can be useful, e.g., in the treatment of disorders responsive to the inhibition of apoptosis signal-regulating kinase 1 (ASK1).