558465-93-3

Basic information

• Product Name: 2,5-DICHLORO-3-HYDROXYMETHYLPYRIDINE
• Synonyms: 2,5-DICHLORO-3-HYDROXYMETHYLPYRIDINE;(2,5-DICHLORO-3-PYRIDINYL)METHANOL;2,5-Dichloropyridine-3-Methanol;5,6-Dichloropyridine-3-methanol;(2,5-Dichloropyridin-3-yl)methanol;2,5-Dichloro-3-pyridinemethanol
• CAS NO: 558465-93-3
• Molecular Formula: C₆H₅Cl₂NO
• Molecular Weight: 178.02
• EINECS: 125-856-9
• Product Categories: Pyridine;Pyridines;Boronic Acid
• Mol File: 558465-93-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 64-66°
• Boiling Point: 292℃
• Flash Point: 130℃
• Appearance: /
• Density: 1.478
• Vapor Pressure: 0.000883mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 12?+-.0.10(Predicted)
• CAS DataBase Reference: 2,5-DICHLORO-3-HYDROXYMETHYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DICHLORO-3-HYDROXYMETHYLPYRIDINE(558465-93-3)
• EPA Substance Registry System: 2,5-DICHLORO-3-HYDROXYMETHYLPYRIDINE(558465-93-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 558465-93-3(Hazardous Substances Data)

Usage

General Description

2,5-Dichloro-3-hydroxymethylpyridine is a specialized chemical compound that follows the IUPAC system of nomenclature. It is characterized by the presence of pyridine, a heterocyclic aromatic compound with a six-membered ring structure, much like benzene, but one of its carbon atoms is replaced by a nitrogen atom. Its structural formula also indicates the presence of two chlorine atoms (dichloro) at the 2nd and 5th positions, and a hydroxymethyl group at the 3rd position on the pyridine ring. The compound is generally used in scientific and industrial applications, often as a reagent or intermediate in chemical synthesis processes. As with many substances of its type, it should be handled carefully due to potential hazards associated with its use.

InChI:InChI=1/C6H5Cl2NO/c7-5-1-4(3-10)6(8)9-2-5/h1-2,10H,3H2

Upstream product

• 67754-03-4 methyl 2,5-dichloronicotinate 
• 176433-49-1 2,5-dichloropyridine-3-carbaldehyde 
• 59782-85-3 2,5-dichloronicotinic acid 

Downstream Products

• 1386986-57-7 5-chloro-3-(methoxymethyl)picolinic acid 
• 1386986-06-6 5-chloro-3-methoxymethyl-pyridine-2-carbonitrile 
• 1386984-01-5 5-chloro-3-methoxymethyl-pyridine-2-carboxylic acid [3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-amide 
• 1386985-56-3 ((R)-5-{5-[(5-chloro-3-methoxymethyl-pyridine-2-carbonyl)-amino]-2-fluoro-phenyl}-5-difluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl)-carbamic acid tert-butyl ester 

Relevant articles and documents

1-(HET)ARYLSULFONYL-(PYRROLIDINE OR PIPERIDINE)-2-CARBOXAMIDE DERIVATIVES AND THEIR USE AS TRPA1 ANTAGONISTS

The invention is concerned with the compounds of formula I and salts thereof and other compounds of formulas II-IX as disclosed herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formulas I-IX as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain or asthma.

Bridged 5,6,7,8-tetrahydro-1,6-naphthyridines, analogues of huperzine A: Synthesis, modelling studies and evaluation as inhibitors of acetylcholinesterase

Derivatives of 6,8-bridged 5,6,7,8-tetrahydro-1,6-naphthyrid-ines, designed as analogues of huperzine A, were synthe-sised and evaluated as inhibitors of acetylcholinesterase. In a first approach, C3-bridged naphthyridines were constructed by internal nucleophilic aromatic substitution of 2-chloro-3-(1-piperidinylmethyl)pyridine precursors containing a 3-CO 2Me group on the 1-piperidinyl ring moiety. Alternatively, ring-closing metathesis on 6,8-diallyl-substituted tetrahydro-1,6-naphthyridines was applied to construct an unsaturated C4 bridge. Some of the target compounds showed inhibition of acetylcholinesterase but lower than that of huperzine A. The relative order of inhibition activities could be rationalised by comparative docking simulation studies on the basis of the known crystal structure of the ace-tylcholinesterase-huperzine A complex.