5588-21-6

Basic information

• Product Name: Cintramide
• Synonyms: Cintramide;Cintriamide;3-(3,4,5-Trimethoxyphenyl)propenamide;C.I.34746
• CAS NO: 5588-21-6
• Molecular Formula: C₁₂H₁₅NO₄
• Molecular Weight: 237.25
• Mol File: 5588-21-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 449.2°Cat760mmHg
• Flash Point: 233.9°C
• Appearance: /
• Density: 1.167g/cm³
• Vapor Pressure: 2.93E-08mmHg at 25°C
• Refractive Index: 1.56
• CAS DataBase Reference: Cintramide(CAS DataBase Reference)
• NIST Chemistry Reference: Cintramide(5588-21-6)
• EPA Substance Registry System: Cintramide(5588-21-6)

Safety Data

• Hazardous Substances Data: 5588-21-6(Hazardous Substances Data)

Usage

Uses

Antipsychotic.

InChI:InChI=1/C12H15NO4/c1-15-9-6-8(4-5-11(13)14)7-10(16-2)12(9)17-3/h4-7H,1-3H3,(H2,13,14)/b5-4+

Upstream product

• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 90-50-6 3,4,5-trimethoxycinnamic acid 
• 5464-68-6 diethyl carbamoylmethylphosphonate 
• 20329-98-0 (E)-3,4,5-trimethoxy-cinnamic acid 
• 10263-19-1 (E)-3-(3,4,5-trimethoxyphenyl)acryloyl chloride 

Relevant articles and documents

Senolytic activity of piperlongumine analogues: Synthesis and biological evaluation

Selective clearance of senescent cells (SCs) has emerged as a potential therapeutic approach for age-related diseases, as well as chemotherapy- and radiotherapy-induced adverse effects. Through a cell-based phenotypic screening approach, we recently identified piperlongumine (PL), a dietary natural product, as a novel senolytic agent, referring to small molecules that can selectively kill SCs over normal or non-senescent cells. In an effort to establish the structure-senolytic activity relationships of PL analogues, we performed a series of structural modifications on the trimethoxyphenyl and the α,β-unsaturated δ-valerolactam rings of PL. We show that modifications on the trimethoxyphenyl ring are well tolerated, while the Michael acceptor on the lactam ring is critical for the senolytic activity. Replacing the endocyclic C2–C3 olefin with an exocyclic methylene at C2 render PL analogues 47–49 with increased senolytic activity. These α-methylene containing analogues are also more potent than PL in inducing ROS production in WI-38 SCs. Similar to PL, 47–49 reduce the protein levels of oxidation resistance 1 (OXR1), an important oxidative stress response protein that regulates the expression of a variety of antioxidant enzymes, in cells. This study represents a useful starting point toward the discovery of senolytic agents for therapeutic uses.

Novel Urea Compounds, Preparation Methods and Uses Thereof

The invention provides a compound of Formula I, an isomer, a pharmaceutically acceptable salt, or a solvate thereof, and use thereof in manufacture of a medicament for preventing and/or treating a drug-resistant tumor or disease or disorder caused by a drug-resistant bacterium, or use thereof in manufacture of a medicament for preventing and/or treating a tumor, a neurodegenerative disease, an allogeneic graft rejection, or an infection-associated disease or disorder; preferably, the tumor, neurodegenerative disease, allogeneic graft rejection, or infection-associated disease or disorder is a disease or disorder caused by Heat shock protein 70 (Hsp70). The compounds of the invention, which are a class of Hsp70 inhibitors having a novel structure and a high activity, solve the problem concerning drug resistance of tumors, enhance the effect of treating tumors, and provide a new medical strategy for treatment of tumors in clinic.

Improvements in or relating to avian control

-