5588-33-0 Usage
Description
Mesoridazine, also known as Thioridazine EP Impurity B, is a phenothiazine derivative with a methylsulfinyl group at position 2 (para to the sulfur atom) and a 2-(1-methylpiperidin-2-yl)ethyl group on the nitrogen atom. It is characterized by its pale pink solid appearance and is primarily recognized for its antipsychotic properties.
Uses
Used in Pharmaceutical Industry:
Mesoridazine is used as an antipsychotic agent for the treatment of various psychiatric disorders, such as schizophrenia and other psychotic conditions. It helps in managing symptoms like hallucinations, delusions, and disorganized thinking by targeting specific receptors in the brain.
Additionally, due to its chemical properties and antipsychotic effects, mesoridazine may also be utilized in research and development for the creation of new pharmaceutical compounds with improved efficacy and reduced side effects.
Therapeutic Function
Tranquilizer
Check Digit Verification of cas no
The CAS Registry Mumber 5588-33-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,5,8 and 8 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 5588-33:
(6*5)+(5*5)+(4*8)+(3*8)+(2*3)+(1*3)=120
120 % 10 = 0
So 5588-33-0 is a valid CAS Registry Number.
InChI:InChI=1/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
5588-33-0Relevant articles and documents
Facile syntheses of the three major metabolites of thioridazine
Morrow, Ryan J.,Millership, Jeff S.,Collier, Paul S.
, p. 962 - 967 (2007/10/03)
Efficient, mild syntheses of the three major metabolites 2-4 of the important antipsychotic drug thioridazine (1) have been developed. The cardiotoxic metabolite 2 with a ring sulfoxide moiety was prepared in 96% yield by oxidation of 1 with NaIO4 under acidic conditions. Four different procedures were elaborated for the selective side-chain sulfide oxidation of 1 to mesoridazine (3), giving rise to yields of up to 91%. Finally, sulforidazine (4) was synthesised via oxidation of the sulfoxide 3 in the presence of either KMnO4 or t-BuOOH under basic conditions. Except for the oxidation with t-BuOOH. all reactions took place under mild conditions within a few minutes, were nicely reproducible, and afforded medium-to-high yields of the desired products, which could be readily purified by column chromatography.
Stability of some phenothiazine free radicals.
Levy,Tozer,Tuck,Loveland
, p. 898 - 905 (2007/10/10)
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