55883-22-2

Basic information

• Product Name: 1-chloro-3-(2-nitrophenoxy)propan-2-ol
• CAS NO: 55883-22-2
• Molecular Formula: C₉H₁₀ClNO₄
• Molecular Weight: 231.633
• Mol File: 55883-22-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 408.7°C at 760 mmHg
• Flash Point: 201°C
• Density: 1.382g/cm³
• Vapor Pressure: 2.06E-07mmHg at 25°C
• Refractive Index: 1.571
• CAS DataBase Reference: 1-chloro-3-(2-nitrophenoxy)propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloro-3-(2-nitrophenoxy)propan-2-ol(55883-22-2)
• EPA Substance Registry System: 1-chloro-3-(2-nitrophenoxy)propan-2-ol(55883-22-2)

Safety Data

• Hazardous Substances Data: 55883-22-2(Hazardous Substances Data)

Usage

Contains

Chlorine atom, nitro group, hydroxyl group

Type of compound

Synthetic organic compound

Industrial applications

Intermediate in the synthesis of pharmaceuticals, agrochemicals, and dyes

Potential hazards

Toxic and harmful to the environment

Precautions

Handle and use with caution due to potential hazards.

Upstream product

• 88-75-5 2-hydroxynitrobenzene 
• 106-89-8 epichlorohydrin 
• 21407-49-8 2-nitrophenyl glycidyl ether 

Downstream Products

• 21407-49-8 2-nitrophenyl glycidyl ether 
• 131513-32-1 1-Morpholin-4-yl-3-(2-nitro-phenoxy)-propan-2-ol 
• 131513-33-2 3-(4-morpholinyl)-1-(2-nitrophenoxy)-2-propanone 
• 72742-66-6 1-[[2-(3-indolyl)-1,1-dimethylethyl]amino]-3-(2-nitrophenoxy)-2-propanol 
• 77216-38-7 1-(2-aminophenoxy)-3-[[2-(3-indolyl)-1,1-dimethylethyl]amino]-2-propanol 
• 1222178-09-7 (R)-1-chloro-3-(2-nitrophenoxy)prop-2-yl acetate 
• 1222178-10-0 (S)-1-chloro-3-(2-nitrophenoxy)prop-2-yl acetate 
• 91089-84-8 (+/-)-1-chloro-3-(2-nitrophenoxy)prop-2-yl acetate 

Relevant articles and documents

Regioselective cleavage of 2-aryloxymethyloxiranes to 3-aryloxy-l- halogenopropan-2-ols

A series of new 2-ary loxymethy loxiranes prepared from epichlorohydrin and substituted phenols was subjected to nucleophilic opening of the oxirane ring. A comparison of regioselectivity and product yield for oxirane cleavage by means of aqueous hydrohalogenic acids or lithium tetrahalogenocuprates under anhydrous conditions was performed. The latter method provided very high regioselectivity for 3-aryloxy-l-halo-genopropan-2-ols as well as excellent yields.

Antihypertensive indole derivatives of phenoxypropanolamines with β-adrenergic receptor antagonist and vasodilating activity

A series of 25 aryloxypropanolamines containing the 3-indolyl-tert-butyl[i.e., 1,1-dimethyl-2-(1H-indol-3-yl)ethyl] or substituted 3-indolyl-tert-butyl moiety as the N substituent is reported. These compounds have been tested for antihypertensive activity in spontaneously hypertensive rats (SHR), β-adrenergic receptor antagonist action in conscious normotensive rats, vasodilating activity in ganglion-blocked rats with blood pressure maintained by angiotensin II infusion, and for intrinsic sympathomimetic action (ISA) in reserpinized rats. Some of the compounds exhibit antihypertensive activity in combination with β-adrenergic receptor antagonist and vasodilating action. The structure-activity relationships in these tests are discussed.