55883-45-9Relevant articles and documents
Conversion of Aryl Aldehydes to Benzyl Iodides and Diarylmethanes by H3PO3/I2
Lv, Fang,Xiao, Jing,Xiang, Junchun,Guo, Fengzhe,Tang, Zi-Long,Han, Li-Biao
, p. 3081 - 3088 (2021/02/01)
For the first time, H3PO3 was used as both the reducing reagent and the promotor in the reductive benzylation reactions with aryl aldehydes. By using a H3PO3/I2 combination, various aromatic aldehydes underwent iodination reactions and Friedel-Crafts type reactions with arenes via benzyl iodide intermediates, readily producing benzyl iodides and diarylmethanes in good yields. Intramolecular cyclization reactions also took place, giving the corresponding cyclic compounds. This new strategy features easy-handling, low-cost, and metal-free conditions.
Direct Trifluoromethoxylation without OCF3-Carrier through In Situ Generation of Fluorophosgene
Donnard, Morgan,Guérin, Thomas,Hanquet, Gilles,Leroux, Frédéric R.,Panossian, Armen,Saiter, Jérémy
supporting information, p. 3139 - 3147 (2021/06/26)
Owing to the high interest in the OCF3 group for pharmaceutical and agrochemical applications, trifluoromethoxylation received great attention in the last years with several new methods for this approach towards OCF3-comprising compounds. Yet, it most often requires the beforehand preparation of specific F3CO? transfer reagents, which can be toxic, expensive, unstable, and/or generate undesired side-products upon consumption. To circumvent this, the in-situ generation of gaseous fluorophosgene from triphosgene, its conversion by fluoride into the OCF3 anion, and the direct use of the latter in nucleophilic substitutions is an appealing strategy, which, although recently approached, has not been fully exploited. We disclose herein our efforts towards this aim.
Method for preparing benzyl iodide and derivatives thereof
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Paragraph 0032-0034, (2020/06/24)
The invention discloses a method for efficiently preparing benzyl iodide and derivatives thereof. The preparation method is characterized in that a benzyl alcohol compound, iodine and hydrogen are used as the reaction raw materials and rhodium and phosphine ligand are used as the catalyst to perform one-step reaction in an organic solvent under a positive pressure condition to synthesize the target benzyl iodide and the derivatives thereof, and the reaction formula of the reaction is as shown in the specification. The method has the advantages that the iodination of the method can be easily achieved, reaction condition requirements are low, large-scale industrial production can be achieved, the yield of the benzyl iodide can reach 82% or above, and the yield of the derivatives of the benzyl iodide can reach 99% or above; the method is wide in application range, short in process flow, low in raw material cost and applicable to the industrial production of a series of benzyl iodide and the derivatives thereof.