55899-30-4

Basic information

• Product Name: Ethyl 6-broMopyrazolo[1,5-a]pyridine-3-carboxylate
• Synonyms: Ethyl 6-broMopyrazolo[1,5-a]pyridine-3-carboxylate
• CAS NO: 55899-30-4
• Molecular Formula: C10H9BrN2O2
• Molecular Weight: 269.09466
• Mol File: 55899-30-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 119-120 °C(Solv: ligroine (8032-32-4))
• Appearance: /
• Density: 1.60±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -0.46±0.30(Predicted)
• CAS DataBase Reference: Ethyl 6-broMopyrazolo[1,5-a]pyridine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 6-broMopyrazolo[1,5-a]pyridine-3-carboxylate(55899-30-4)
• EPA Substance Registry System: Ethyl 6-broMopyrazolo[1,5-a]pyridine-3-carboxylate(55899-30-4)

Safety Data

• Hazardous Substances Data: 55899-30-4(Hazardous Substances Data)

Usage

General Description

Ethyl 6-bromopyrazolo[1,5-a]pyridine-3-carboxylate is a chemical compound with the molecular formula C12H9BrN2O2. It is commonly used as a building block in the synthesis of pharmaceutical compounds and agrochemicals. ethyl 6-bromopyrazolo[1,5-a]pyridine-3-carboxylate is a derivative of pyrazolo[1,5-a]pyridine, which has been studied for its potential use in the treatment of various diseases, including cancer, Alzheimer's disease, and inflammation. The presence of the bromine atom in its structure provides unique reactivity, making it valuable in the development of novel drugs and functional materials. Its ethyl ester form allows for easier handling and manipulation in laboratory settings, making it a widely used reagent in organic synthesis.

Upstream product

• 623-47-2 propynoic acid ethyl ester 
• 626-55-1 3-Bromopyridine 
• 36474-98-3 1-amino-3-bromopyridinium iodide 
• 55899-13-3 1-amino-3-bromopyridin-1-ium 2,4,6-trimethylbenzenesulfonate 
• 1060814-88-1 ethyl 2-(5-bromopyridin-2-yl)acetate 

Downstream Products

• 1207557-16-1 ethyl 6-(4-fluorophenyl)pyrazolo[1,5-a]pyridine-3-carboxylate 
• 1264193-11-4 6- bromopyrazolo[1,5-a]pyridine 
• 1356145-14-6 N'-((6-bromopyrazolo[1,5-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide 

Relevant articles and documents

SUBSTITUTED FUSED AROMATIC RING DERIVATIVE, COMPOSITION AND USE THEREOF

Provided are a substituted fused aromatic ring derivative, a composition containing the compound, and a use thereof. The substituted fused aromatic ring derivative is a compound represented by formula (I) or a tautomer, stereoisomer, prodrug, crystal form, pharmaceutically acceptable salt, hydrate or solvate thereof. The compound and the composition can be used to treat various protein tyrosine kinase-mediated diseases or disorders.

In Situ Preparation and Consumption of O -Mesitylsulfonylhydroxylamine (MSH) in Continuous Flow for the Amination of Pyridines

The paper demonstrates a safe method in which highly unstable O -mesitylsulfonylhydroxylamine (MSH) can be prepared and consumed in continuous flow. MSH was prepared in situ and used for the flow amination of a range of pyridines, which were subsequently transformed into useful pyrazolopyridine building blocks.

BICYCLIC HETEROARYLS AS KINASE INHIBITORS

The invention is directed to heteroaryl compounds useful as inhibitors of various kinase enzymes. In various embodiments, the invention provides a heteroaryl compound having inhibitory bioactivity with respect to a Rho kinase, an AKT kinase, a p70S6K kinase, a LIM kinase, an IKK kinase, a Flt kinase, an Aurora kinase, or a Src kinase, or any combination thereof. Compounds of the invention include bicyclic heteroaryl compounds of formula (I), which can contain a bridging nitrogen atom at a ring junction. The invention further provides methods of synthesis of compounds of the invention, pharmaceutical compositions, pharmaceutical combinations, and methods of treatment of malconditions using compounds of the invention.