5596-87-2

Basic information

• Product Name: 3-(3,4-DIHYDROISOQUINOLIN-2(1H)-YL)PROPAN-1-AMINE
• Synonyms: 3-(3,4-DIHYDROISOQUINOLIN-2(1H)-YL)PROPAN-1-AMINE;3-(3,4-dihydro-1H-isoquinolin-2-yl)propan-1-amine;3-(3,4-dihydro-1H-isoquinolin-2-yl)propylamine;3,4-Dihydro-2(1H)-isoquinolinepropanamine 2HCl
• CAS NO: 5596-87-2
• Molecular Formula: C₁₂H₁₈N₂
• Molecular Weight: 190.29
• Mol File: 5596-87-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 311.2±30.0 °C(Predicted)
• Appearance: /
• Density: 1.028±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 10.06±0.10(Predicted)
• CAS DataBase Reference: 3-(3,4-DIHYDROISOQUINOLIN-2(1H)-YL)PROPAN-1-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,4-DIHYDROISOQUINOLIN-2(1H)-YL)PROPAN-1-AMINE(5596-87-2)
• EPA Substance Registry System: 3-(3,4-DIHYDROISOQUINOLIN-2(1H)-YL)PROPAN-1-AMINE(5596-87-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 5596-87-2(Hazardous Substances Data)

Usage

General Description

3-(3,4-Dihydroisoquinolin-2(1H)-yl)propan-1-amine is a chemical compound that belongs to the class of amines. It is a derivative of isoquinoline and contains a propylamine group. 3-(3,4-DIHYDROISOQUINOLIN-2(1H)-YL)PROPAN-1-AMINE has potential applications in medicinal chemistry, particularly for the development of pharmaceutical drugs. It may have properties that make it suitable for use as a drug candidate for various therapeutic purposes. Further research and investigation are needed to fully understand the potential uses and properties of 3-(3,4-Dihydroisoquinolin-2(1H)-yl)propan-1-amine.

Upstream product

• 198895-33-9 2-[3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]-2,3-dihydro-1H-isoindole-1,3-dione 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 14753-26-5 3-chloropropan-1-amine 
• 5460-29-7 2-(3-bromopropyl)isoindole-1,3-dione 

Downstream Products

• 1201219-09-1 perfluorophenyl 4-(4-(4-(5-(3-(3,4-dihydroisoquinolin-2(1H)-yl)propylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl)benzoyl)benzamido)-1-methyl-1H-pyrrole-2-carboxylate 
• 1351184-57-0 N-(2-aminoethyl)-N-[3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]benzenesulfonamide 
• 1350977-93-3 N-(3-aminopropyl)-N-[3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]benzenesulfonamide 
• 1350977-94-4 N-(3-aminopropyl)-N-[3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]benzenesulfonamide fumarate 

Relevant articles and documents

Highly Selective Butyrylcholinesterase Inhibitors with Tunable Duration of Action by Chemical Modification of Transferable Carbamate Units Exhibit Pronounced Neuroprotective Effect in an Alzheimer's Disease Mouse Model

In this study, the carbamate structure of pseudo-irreversible butyrylcholinesterase (BChE) inhibitors was optimized with regard to a longer binding to the enzyme. A set of compounds bearing different heterocycles (e.g., morpholine, tetrahydroisoquinoline, benzimidazole, piperidine) and alkylene spacers (2 to 10 methylene groups between carbamate and heterocycle) in the carbamate residue was synthesized and characterized in vitro for their binding affinity, binding kinetics, and carbamate hydrolysis. These novel BChE inhibitors are highly selective for hBChE over human acetycholinesterase (hAChE), yielding short-, medium-, and long-acting nanomolar hBChE inhibitors (with a half-life of the carbamoylated enzyme ranging from 1 to 28 h). The inhibitors show neuroprotective properties in a murine hippocampal cell line and a pharmacological mouse model of Alzheimer's disease (AD), suggesting a significant benefit of BChE inhibition for a disease-modifying treatment of AD.

Solution-phase parallel synthesis of novel membrane-targeted antibiotics

The increase in the incidence of antibiotic-resistant infections is a major concern to healthcare workers and requires the development of novel antibacterial agents. Recently, we described a series of benzophenonecontaining antibiotics which displayed activity against antibiotic-resistant bacteria. We have shown that these agents function by disrupting the bacterial membrane. To further explore these compounds, a practical and efficient solution-phase parallel synthesis method was developed which allowed us to prepare combinatorial libraries of these agents. Using this method, we prepared 218 compounds in 58 reactions. All of the compounds were characterized by HPLC and MALDI-TOF mass spectrometry. Analysis of this library for antibacterial activity identified six compounds which displayed MTC values of 2.0 mg/T. against Staphylococcus aureus. Examination of the structure-function relationships of these agents revealed that cationic groups were required and that cyclic, aliphatic amines were crucial for activity. Using the information generated here, we speculate on how the various structural features of the molecule are necessary for the interaction with the bacterial membrane.