55982-12-2

Basic information

• Product Name: 2-amino-6-(2-methoxy-phenyl)-3H-pyrimidin-4-one
• Synonyms: 2-amino-6-(2-methoxy-phenyl)-3H-pyrimidin-4-one
• CAS NO: 55982-12-2
• Molecular Weight: 217.227
• Mol File: 55982-12-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-amino-6-(2-methoxy-phenyl)-3H-pyrimidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-6-(2-methoxy-phenyl)-3H-pyrimidin-4-one(55982-12-2)
• EPA Substance Registry System: 2-amino-6-(2-methoxy-phenyl)-3H-pyrimidin-4-one(55982-12-2)

Safety Data

• Hazardous Substances Data: 55982-12-2(Hazardous Substances Data)

Upstream product

• 41607-95-8 3-(2-methoxy-phenyl)-3-oxo-propionic acid ethyl ester 
• 593-85-1 diguanidine carbonate 
• 113-00-8 guanidine nitrate 

Downstream Products

• 74602-66-7 2-Amino-5-iodo-6-(2-methoxy-phenyl)-3H-pyrimidin-4-one 
• 74602-65-6 2-Amino-5-bromo-6-(2-methoxy-phenyl)-3H-pyrimidin-4-one 
• 74602-64-5 2-Amino-5-chloro-6-(2-methoxy-phenyl)-3H-pyrimidin-4-one 

Relevant articles and documents

Improved synthesis of sterically encumbered heteroaromatic biaryls from aromatic β-keto esters

A protocol for the synthesis of hindered 4-aryl 2-aminopyrimidines from β–keto esters is described. The process employs trifluoroethanol as an essential additive to promote the guanidine condensation reaction, enabling the synthesis of 25 aryl- and heteroaryl substituted aminopyrimidines in good yields and high purities with no column chromatography. The conditions described herein are readily scalable and have been employed in the large-scale synthesis of the clinical A2a/A2bR antagonist AB928.

Research on antitumor agents. XI. Formation of pyrimidine derivatives from 4 hydroxy and 4 ethoxycoumarins

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