55983-56-7Relevant articles and documents
Antitumour Imidazotetrazines. Part 12. Reactions of Mitozolomide and its 3-Alkyl Congeners with Oxygen, Nitrogen, Halogen, and Carbon Nucleophiles
Baig, Ghouse Unissa,Stevens, Malcolm F. G.
, p. 665 - 670 (2007/10/02)
Mitozolomide (1) and its 3-alkyl congeners ring-open in aqueous sodium carbonate to form 5-(3-alkyltriazen-1-yl)imidazole-4-carboxamides.The 3-methyl and 3-ethyl analogues of mitozolomide decompose in alcohols to form 2-azahypoxanthine and 5-amino-1-alkoxycarbonylimidazole-4-carboxamides.In hydrazine hydrate mitozolomide yields, principally, 5-azidoimidazole-4-carboxamide, whereas the 3-alkyl-derivatives form 5-amino-4-carbamoylimidazole-1-carbohydrazide. 5-Diazoimidazole-4-carboxamide, generated by thermolysis of mitozolomide in acetic acid or pyridine, can be trapped by reactive methylenic ketones, nitriles or esters to afford imidazotriazines.