560082-53-3 Usage
Description
6-Bromo-8-fluoro-2H-benzo[b][1,4]oxazin-3(4H)-one is a chemical compound belonging to the class of benzoxazinone derivatives. It is characterized by the presence of a bromine atom at the 6th position and a fluorine atom at the 8th position in its molecular structure. 6-Bromo-8-fluoro-2H-benzo[b][1,4]oxazin-3(4H)-one exhibits unique chemical properties and reactivity due to the presence of these halogens, making it a valuable intermediate in the synthesis of various biologically active molecules.
Uses
Used in Pharmaceutical Industry:
6-Bromo-8-fluoro-2H-benzo[b][1,4]oxazin-3(4H)-one is used as a reactant for the preparation of benzoxazinone derivatives. These derivatives have been found to possess potent and selective nonsteroidal mineralocorticoid receptor antagonistic properties, making them valuable in the development of new drugs for the treatment of various medical conditions, such as hypertension and heart failure.
Used in Chemical Synthesis:
Due to its unique structural features, 6-Bromo-8-fluoro-2H-benzo[b][1,4]oxazin-3(4H)-one can be employed as a versatile building block in the synthesis of a wide range of chemical compounds. Its reactivity can be exploited in various chemical reactions, such as substitution, addition, and condensation, to generate a diverse array of molecules with potential applications in various fields, including pharmaceuticals, agrochemicals, and materials science.
Used in Research and Development:
6-Bromo-8-fluoro-2H-benzo[b][1,4]oxazin-3(4H)-one can also be utilized as a research tool in the study of the structure-activity relationships of benzoxazinone derivatives. By investigating the effects of various structural modifications on the biological activity of these compounds, researchers can gain valuable insights into the design and development of more effective and selective mineralocorticoid receptor antagonists.
Check Digit Verification of cas no
The CAS Registry Mumber 560082-53-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,6,0,0,8 and 2 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 560082-53:
(8*5)+(7*6)+(6*0)+(5*0)+(4*8)+(3*2)+(2*5)+(1*3)=133
133 % 10 = 3
So 560082-53-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H5BrFNO2/c9-4-1-5(10)8-6(2-4)11-7(12)3-13-8/h1-2H,3H2,(H,11,12)
560082-53-3Relevant articles and documents
PYRIDIN-2-ONE DERIVATIVES OF FORMULA (II) USEFUL AS EP3 RECEPTOR ANTAGONISTS
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Paragraph 1227; 1231; 1232, (2019/02/24)
The present invention is directed to pyridin-2-one derivatives, pharmaceutical compositions containing them and their use as antagonists of the EP3 receptor, for the treatment of for example, impaired oral glucose tolerance, elevated fasting glucose, Type II Diabetes Mellitus, Syndrome X (also known as Metabolic Syndrome) and related disorders and complications thereof.
PYRIDIN-2-ONE DERIVATIVES OF FORMULA (III) USEFUL AS EP3 RECEPTOR ANTAGONISTS
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Paragraph 1217-1218, (2019/02/24)
The present invention is directed to pyridin-2-one derivatives, pharmaceutical compositions containing them and their use as antagonists of the EP3 receptor, for the treatment of for example, impaired oral glucose tolerance, elevated fasting glucose, Type II Diabetes Mellitus, Syndrome X (also known as Metabolic Syndrome) and related disorders and complications thereof.
Tetrahydroquinoline analogues as muscarinic agonists
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Page/Page column 33, (2017/01/05)
The present invention relates to tetrahydroquinoline compounds as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with said compounds; methods of treating a disease condition associated with a muscarinic receptor using said compounds; and methods for identifying a subject suitable for treatment using said compounds.
