5601-45-6

Basic information

• Product Name: 1-Morpholino-4-methyl-1-cyclohexene
• Synonyms: 1-Morpholino-4-methyl-1-cyclohexene;4-(4-Methyl-1-cyclohexen-1-yl)morpholine
• CAS NO: 5601-45-6
• Molecular Formula: C₁₁H₁₉NO
• Molecular Weight: 181.2747
• Mol File: 5601-45-6.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 284.5°Cat760mmHg
• Flash Point: 83.8°C
• Appearance: /
• Density: 1.007g/cm³
• Vapor Pressure: 0.00297mmHg at 25°C
• Refractive Index: 1.508
• CAS DataBase Reference: 1-Morpholino-4-methyl-1-cyclohexene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Morpholino-4-methyl-1-cyclohexene(5601-45-6)
• EPA Substance Registry System: 1-Morpholino-4-methyl-1-cyclohexene(5601-45-6)

Safety Data

• Hazardous Substances Data: 5601-45-6(Hazardous Substances Data)

Usage

Chemical structure

1-Morpholino-4-methyl-1-cyclohexene consists of a cyclohexene ring with a morpholino group attached at the 1-position and a methyl group at the 4-position.

Usage

It serves as an important intermediate for the synthesis of pharmaceuticals and agrochemicals.

Application in organic synthesis

1-Morpholino-4-methyl-1-cyclohexene is used as a building block for creating more complex molecules.

Potential applications

The compound has been studied for its potential applications in materials science and as a catalyst in certain chemical reactions.

Versatility

This compound has versatile uses in various fields, making it a valuable tool in chemical research and development.

InChI:InChI=1/C11H19NO/c1-10-2-4-11(5-3-10)12-6-8-13-9-7-12/h4,10H,2-3,5-9H2,1H3

Upstream product

• 110-91-8 morpholine 
• 589-92-4 1-methylcyclohexan-4-one 

Downstream Products

• 5601-49-0 4-Methyl-2-propionyl-cyclohexanon 
• 36771-33-2 4-(4-methyl-cyclohex-1-enyl)-3-phenyl-2H-isoxazol-5-one; compound with morpholine (1:1) 
• 28339-02-8 2-(2-Methylbutyryl)-4-methylcyclohexanon 
• 67861-35-2 4-[4-methyl-6-(2-nitro-1-phenyl-ethyl)-cyclohex-1-enyl]-morpholine 
• 67861-36-3 4-{6-[1-(4-methoxy-phenyl)-2-nitro-ethyl]-4-methyl-cyclohex-1-enyl}-morpholine 
• 67861-38-5 2-methoxy-4-[1-(5-methyl-2-morpholin-4-yl-cyclohex-2-enyl)-2-nitro-ethyl]-phenol 
• 29441-75-6 6-methyl-8a-morpholin-4-yl-3-phenyl-4a,5,6,7,8,8a-hexahydro-4H-benzo[e][1,2]oxazine 
• 62115-82-6 2-Isobutyryl-4-methylcyclohexanon 
• 77120-57-1 2-[(2-Methoxy-phenyl)-hydrazono]-4-methyl-cyclohexanone 
• 96835-86-8 6-Methyl-3-phenyl-5,6,7,8-tetrahydro-4H-cinnoline-1-carboxylic acid amide 
• 96835-85-7 8a-Hydroxy-6-methyl-3-phenyl-4a,5,6,7,8,8a-hexahydro-4H-cinnoline-1-carboxylic acid amide 
• 96835-89-1 6-Methyl-8a-morpholin-4-yl-3-phenyl-4a,5,6,7,8,8a-hexahydro-4H-cinnoline-1-carboxylic acid amide 
• 61592-64-1 cis-2-acetoxy-4-methylcyclohexanone 
• 84736-51-6 cis-2-(4-methoxyphenyl)-4-methylcyclohexanone 

Relevant articles and documents

First zinc bromide promoted annulative domino reactions between enamines and cyclic Morita-Baylis-Hillman alcohols: Synthesis of N, O-ketals

A new efficient ZnBr 2-mediated annulative domino reaction between enamines and cyclic Morita-Baylis-Hillman (MBH) alcohols is disclosed. The process involves a tandem sequence (intermolecular conjugate addition of enamines to MBH alcohols and intramolecular nucleophilic addition of the hydroxyl moiety to the transiently generated iminium ion), affording the corresponding N, O -ketals diastereoselectively in good yields.

Direct palladium-catalyzed allylic alkylations of alcohols with enamines: Synthesis of homoallyl ketones

An efficient, direct nucleophilic allylic substitution of α-, β- and γ-substituted alcohols with enamines, using the Pd(OAc)2/PPh3 catalyst system and ZnBr2 as a promoter in CH2Cl2 at reflux, is reported. The reaction course was dependent on the steric hindrance at the α- or γ-positions with respect to the functionalized α-carbon, selectively affording in moderate to good yields, α- or γ-homoallyl ketones, the so-called “linear” and “branched” products, respectively.

Direct Regio- and Diastereoselective Diphosphonylation of Cyclic Enamines: One-Pot Synthesis of α,α'-Bis(diphenylphosphoryl)- and α,α'-Bis(diphenylphosphorothioyl)cycloalkanones

A straightforward regio- and diastereoselective process has been developed for the synthesis of unprecedented symmetrical trans -α,α'-bis(diphenylphosphoryl)- and α,α'-bis(diphenylphosphorothioyl)-cycloalkanones, through the reaction of cyclic enamines with excess P -chlorodiphenylphosphine in the presence of triethylamine, followed by oxidation or sulfurization and hydrolytic workup.