5601-74-1

Basic information

• Product Name: OPHIOBOLIN B
• Synonyms: OPHIOBOLIN B;3,14-Dihydroxy-5-oxoophiobola-7,19-dien-25-al;Cochliobolin B;Cochliobolin B, Zizanin B, Ophiobolsin A
• CAS NO: 5601-74-1
• Molecular Formula: C25H38O4
• Molecular Weight: 402.57
• Mol File: 5601-74-1.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: OPHIOBOLIN B(CAS DataBase Reference)
• NIST Chemistry Reference: OPHIOBOLIN B(5601-74-1)
• EPA Substance Registry System: OPHIOBOLIN B(5601-74-1)

Safety Data

• Hazardous Substances Data: 5601-74-1(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 5601-74-1 differently. You can refer to the following data:
1. Ophiobolin B is a minor member of a class of phytotoxic metabolites produced by Bipolaris and other genera of plant pathogenic fungi. Ophiobolin B acts by inhibiting calmodulin action in calcium regulation.
2. Calmodulin is a calcium-sensing protein that regulates a wide array of proteins involved in diverse cellular functions. Ophiobolin B is a sesterterpenoid fungal phytotoxin that binds and irreversibly antagonizes calmodulin, producing cytotoxic and antimicrobial effects. It induces apoptosis in chronic lymphocytic leukemia cells with an LC50 value of 2 nM and in different zygomycetes with MIC values ranging from 25-50 μg/ml.[Cayman Chemical]
3. Ophiobolin B is a fungal phytotoxin and inhibits calmodulin (a protein involved in calcium regulation). Ophiobolin B also exhibit antibacterial and antitumor activities.