5602-34-6

Basic information

• Product Name: 1,4-dimorpholin-4-ylbut-2-ene-1,4-dione
• Synonyms: 1,4-dimorpholin-4-ylbut-2-ene-1,4-dione
• CAS NO: 5602-34-6
• Molecular Formula: C12H18N2O4
• Molecular Weight: 254.28
• Mol File: 5602-34-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 519.8°C at 760 mmHg
• Flash Point: 268.1°C
• Appearance: /
• Density: 1.242g/cm³
• Vapor Pressure: 6.63E-11mmHg at 25°C
• Refractive Index: 1.534
• CAS DataBase Reference: 1,4-dimorpholin-4-ylbut-2-ene-1,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-dimorpholin-4-ylbut-2-ene-1,4-dione(5602-34-6)
• EPA Substance Registry System: 1,4-dimorpholin-4-ylbut-2-ene-1,4-dione(5602-34-6)

Safety Data

• Hazardous Substances Data: 5602-34-6(Hazardous Substances Data)

Usage

Type of compound

1,4-diketone derivative

Structural features

Contains two morpholine groups

Usage

Building block in organic synthesis

Chemical reactivity

Ability to undergo a variety of chemical reactions

Potential applications

Pharmaceutical industry, reagent in chemical reactions

Research focus

Biological activities, role in various chemical processes

Versatility

Range of potential applications in chemistry and pharmaceuticals

InChI:InChI=1/C12H18N2O4/c15-11(13-3-7-17-8-4-13)1-2-12(16)14-5-9-18-10-6-14/h1-2H,3-10H2

Upstream product

• 110-91-8 morpholine 
• 624-49-7 dimethylfumarate 
• 627-63-4 fumaryl dichloride 

Relevant articles and documents

Development of an organo- and enzyme-catalysed one-pot, sequential three-component reaction

A one-pot, three-component process is described which involves both organo- and enzyme-catalysed carbon-carbon bond-forming steps. In the first step, an organocatalyst catalyses the aldol reaction between acetaldehyde and a glyoxylamide. After dilution with additional aqueous buffer, and addition of pyruvate and an aldolase enzyme variant, a second aldol reaction occurs to yield a final product. Crucially, it was possible to develop a reaction in which both the organo- and enzyme-catalysed reactions could be performed in the same aqueous buffer system. The reaction described is the first example of a one-pot, three-component reaction in which the two carbon-carbon bond-forming processes are catalysed using the combination of an organocatalyst and an enzyme.