56041-75-9Relevant articles and documents
Early Development Scale-Up of a Structurally-Challenging 5-Lipoxygenase Activating Protein (FLAP) Inhibitor
Mulder, Jason A.,Gao, Joe,Fandrick, Keith R.,Zeng, Xingzhong,Desrosiers, Jean-Nicolas,Patel, Nitinchandra D.,Li, Zhibin,Rodriguez, Sonia,Lorenz, Jon C.,Wang, Jun,Ma, Shengli,Fandrick, Daniel R.,Grinberg, Nelu,Lee, Heewon,Bosanac, Todd,Takahashi, Hidenori,Chen, Zhidong,Bartolozzi, Alessandra,Nemoto, Peter,Busacca, Carl A.,Song, Jinhua J.,Yee, Nathan K.,Mahaney, Paige E.,Senanayake, Chris H.
, p. 1427 - 1434 (2017/09/22)
A practical and efficient synthesis of the FLAP inhibitor 1 was developed addressing multiple scale-up and safety concerns posed by the established synthesis and utilized a resolution strategy (replacing supercritical fluid chromatography (SFC) separation) for expedient access to the key structural component of 1: the challenging chiral quaternary center. Also highlighted are in situ IR monitoring, condensation to form the 1,2,4-oxadiazole ring, and an efficient Suzuki-Miyaura coupling.
HETEROCYCLIC COMPOUNDS AS INHIBITORS OF LEUKOTRIENE PRODUCTION
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Paragraph 0259; 0260, (2013/08/14)
The present invention relates to compound of formula (I): or pharmaceutically acceptable salts thereof, wherein R1-R7, A and HET are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes
OXADIAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION
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Page/Page column 110-111, (2012/03/11)
The present invention relates to compound of formula (I): or pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.