56073-93-9

Basic information

• Product Name: N-(4-(3-amino-4-nitrophenylthio)phenyl)acetamide
• Synonyms: N-(4-(3-amino-4-nitrophenylthio)phenyl)acetamide
• CAS NO: 56073-93-9
• Molecular Formula: C₁₄H₁₃N₃O₃S
• Molecular Weight: 303.33632
• EINECS: -0
• Mol File: 56073-93-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-(3-amino-4-nitrophenylthio)phenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-(3-amino-4-nitrophenylthio)phenyl)acetamide(56073-93-9)
• EPA Substance Registry System: N-(4-(3-amino-4-nitrophenylthio)phenyl)acetamide(56073-93-9)

Safety Data

• Hazardous Substances Data: 56073-93-9(Hazardous Substances Data)

Upstream product

• 1635-61-6 5-chloro-2-nitroaniline 
• 1126-81-4 4-acetamidothiophenol 

Downstream Products

• 19284-74-3 3,4'-diamino-4-nitrodiphenyl sulphide 
• 433224-09-0 C₂₃H₁₇F₄N₅O₃S 
• 433224-15-8 C₂₃H₁₇F₄N₅O₄S 
• 56073-96-2 methyl N-[5⁽⁶⁾-(4-aminophenylsulfanyl)benzimidazol-2-yl]carbamate 
• 56073-95-1 [5-(4-acetylamino-phenylsulfanyl)-1⁽³⁾H-benzoimidazol-2-yl]-carbamic acid methyl ester 
• 97849-16-6 4-(1H-Benzoimidazol-5-ylsulfanyl)-phenylamine 
• 97849-17-7 4-(2-Methyl-1H-benzoimidazol-5-ylsulfanyl)-phenylamine 
• 97849-26-8 2-amino-5⁽⁶⁾-(4-aminophenylthio)benzimidazole 
• 97849-18-8 4-(1H-Benzoimidazole-5-sulfonyl)-phenylamine 
• 97849-19-9 5-(4-Isothiocyanato-phenylsulfanyl)-1H-benzoimidazole 
• 97849-15-5 5⁽⁶⁾-(4-acetaminophenylsulphono)-2-methylbenzimidazole 
• 97849-20-2 5-(4-Isothiocyanato-phenylsulfanyl)-2-methyl-1H-benzoimidazole 
• 97849-08-6 N-[4-(1H-Benzoimidazol-5-ylsulfanyl)-phenyl]-acetamide 
• 97849-27-9 5-(4-Amino-benzenesulfonyl)-1H-benzoimidazol-2-ylamine 

Relevant articles and documents

Discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors

We herein disclose a novel chemical series of benzimidazole-ureas as inhibitors of VEGFR-2 and TIE-2 kinase receptors, both of which are implicated in angiogenesis. Structure-activity relationship (SAR) studies elucidated a critical role for the N1 nitrogen of both the benzimidazole (segment E) and urea (segment B) moieties. The SAR results were also supported by the X-ray crystallographic elucidation of the role of the N1 nitrogen and the urea moiety when the benzimidazole-urea compounds were bound to the VEGFR-2 enzyme. The left side phenyl ring (segment A) occupies the backpocket where a 3-hydrophobic substituent was favored for TIE-2 activity.

Syntheses of 2,5(6)-Disubstituted Benzimidazoles and 1,4-Disubstituted Piperazines as Potential Antiparasitic Agents

The synthesis of a series of 5(6)-benzimidazoles (13-21), 1-(7-chloroquinolin-4-yl)-4-piperazines (29-30) and 2-substituted 5(6)-(7-chloroquinolin-4-yl