56083-03-5Relevant articles and documents
Synthesis and biological evaluation of chalcones as potential antileishmanial agents
Gupta, Shweta,Shivahare, Rahul,Korthikunta, Venkateswarlu,Singh, Rohit,Gupta, Suman,Tadigoppula, Narender
, p. 359 - 366 (2014/06/09)
Antileishmanial activities of thirty-five synthetic chalcones have been examined. Among them, ten compounds (4, 6, 16, 22, 23, 24, 25, 29, 35 and 37) exhibited potent in vitro activity (IC50 range from 1.70 to 8 μM) against extracellular promastigotes and intracellular amastigotes form of Leishmania donovani. Two promising compounds 22 and 37 were tested in vivo in L. donovani/hamster model. Chalcone 37 showed 83.32% parasite inhibition at a dose of 50 mg/kg for 10 days whereas, 75.89% parasite inhibition at 100 mg/kg dose for 5 days by intraperitoneal route at day 7 post-treatment.
A new route to the synthesis of pyranoflavone and pyranochalcone natural products and their derivatives
Lee, Yong Rok,Kim, Do Hoon
, p. 603 - 608 (2007/10/03)
The total synthesis of biologically active pyranoflavone natural products 1 and 2 was carried out starting from 2H-pyran. The synthesis of pyranochalcone natural products, lonchocarpin (9) and 4-hydroxylonchocarpin (10), and their derivatives 30-32 is des
Selenium-based solid-phase synthesis of benzopyrans I: Applications to combinatorial synthesis of natural products
Nicolaou,Pfefferkorn, Jeffrey A.,Cao, Guo-Qiang
, p. X734-739 (2007/10/03)
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