561-65-9 Usage
Description
18-Hydroxycorticosterone, a derivative of corticosterone, is a 18-hydroxy steroid characterized by the presence of a hydroxy group at the 18th position. It plays a significant role in the synthesis of various steroidal compounds and has potential applications in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
18-Hydroxycorticosterone is used as an intermediate in the synthesis of Aldosterone (A514700), a mineralocorticoid hormone that helps regulate electrolyte balance and blood pressure. Its role in the synthesis process is crucial for the production of this essential hormone.
Used in Steroid Research and Development:
As a steroid derivative, 18-Hydroxycorticosterone can be utilized in research and development of new steroidal compounds with potential therapeutic applications. Its unique structure allows for further modification and exploration of its properties and effects on various biological systems.
Used in Hormone Replacement Therapy:
Due to its structural similarity to corticosterone, 18-Hydroxycorticosterone may also find applications in hormone replacement therapy, particularly for conditions where the balance of steroidal hormones needs to be maintained or restored. However, further research and clinical trials would be necessary to establish its efficacy and safety in such applications.
Check Digit Verification of cas no
The CAS Registry Mumber 561-65-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,6 and 1 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 561-65:
(5*5)+(4*6)+(3*1)+(2*6)+(1*5)=69
69 % 10 = 9
So 561-65-9 is a valid CAS Registry Number.
InChI:InChI=1/C21H30O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,14-17,19,22-23,25H,2-7,9-11H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1
561-65-9Relevant articles and documents
Ulick et al.
, p. 6421 (1960)
Cytotoxic nucleoside-corticosteroid phosphodiesters
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, (2008/06/13)
Nucleotides of nucleosides or bases having known cytotoxic activity are reacted with steroids, preferably corticosteroids, to form corresponding cytotoxic nucleoside-corticosteroid phosphodiester analogues of the formula: STR1 wherein: steroid is the residue formed by removal of a hydroxyl hydrogen atom from a natural or synthetic adrenal corticosteroid containing the characteristic cyclopentanophenanthrene nucleus which is esterified to the phosphate moiety at the 21-position; sugar is a naturally occurring pentose or deoxypentose in the furanose form, preferably ribose, deoxyribose, lyxose, xylose or arabinose and especially ribose, deoxyribose or arabinose, which is esterified to the phosphate moiety at the 5'-position and covalently bonded to the heterocycle moiety at the 1'-position to form a nucleoside; and heterocycle is a purine, pyrimidine, hydrogenated pyrimidine, triazolopurine or similar nucleoside base. The conjugates exhibit an enhanced therapeutic index as compared to the parent nucleoside or base compounds, and are thus useful cytotoxic, antiviral and antineoplastic agents.
