56139-08-3

Basic information

• Product Name: 3,4-DIMETHOXYBENZHYDROL
• Synonyms: 3,4-DIMETHOXYBENZHYDROL
• CAS NO: 56139-08-3
• Molecular Formula: C₁₅H₁₆O₃
• Molecular Weight: 244.29
• Mol File: 56139-08-3.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3,4-DIMETHOXYBENZHYDROL(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DIMETHOXYBENZHYDROL(56139-08-3)
• EPA Substance Registry System: 3,4-DIMETHOXYBENZHYDROL(56139-08-3)

Safety Data

• Hazardous Substances Data: 56139-08-3(Hazardous Substances Data)

Usage

General Description

3,4-Dimethoxybenzhydrol is a chemical compound that is commonly used in organic synthesis as an intermediate in the production of pharmaceuticals and other organic compounds. It is an aromatic compound with two methoxy groups attached to the benzene ring, and a hydroxyl group attached to the fourth carbon atom. 3,4-Dimethoxybenzhydrol is often used as a building block in the synthesis of various drugs and other biologically active compounds. It is also used as an intermediate in the production of fragrances and flavoring agents. Overall, 3,4-Dimethoxybenzhydrol is a versatile and important chemical compound in the field of organic chemistry and pharmaceutical synthesis.

Upstream product

• 4038-14-6 3,4-dimethoxybenzophenone 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 100-58-3 phenylmagnesium bromide 
• 100-52-7 benzaldehyde 
• 98-80-6 phenylboronic acid 
• 108-86-1 bromobenzene 
• 67-63-0 isopropyl alcohol 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 

Downstream Products

• 36317-54-1 β-phenyl-β-(3,4-dimethoxyphenyl)propionic acid 
• 4038-14-6 3,4-dimethoxybenzophenone 
• 23731-46-6 4-(chloro-phenyl-methyl)-1,2-dimethoxy-benzene 
• 191112-95-5 N-(2,2-Dimethoxy-ethyl)-N-[(3,4-dimethoxy-phenyl)-phenyl-methyl]-C-phenyl-methanesulfonamide 
• 20412-84-4 2-ethyl-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 4029-09-8 6,7-dimethoxy-1-phenyl-isoquinoline 
• 191113-01-6 6,7-Dimethoxy-1-phenyl-2-phenylmethanesulfonyl-1,2-dihydro-isoquinoline 
• 23731-48-8 1-<3,4-Dimethoxy-phenyl>-1-phenyl-dimethylamin 

Relevant articles and documents

Employing Arynes for the Generation of Aryl Anion Equivalents and Subsequent Reaction with Aldehydes

Arynes are highly reactive intermediates, which are utilized for the electrophilic arylation of various X-H bonds (X = O, N, S etc.). Herein, a new synthetic strategy is demonstrated, where arynes are converted into aryl anion equivalents by treatment with phosphines and a base. The addition of phosphines to arynes form the phosphonium salts, which in the presence of a carbonate base generates the aryl anion equivalent. Subsequent addition of the aryl anions with aldehydes afforded the secondary alcohols.

An unusual chemoselective oxidation strategy by an unprecedented exploration of an electrophilic center of DMSO: A new facet to classical DMSO oxidation

A conceptually new dimethyl sulfoxide (DMSO) based oxidation process without the use of any activator has been demonstrated for the oxidation of active methylenes and benzhydrols. The developed protocol utilizes the electrophilic center of DMSO for oxidation, which was unexplored before. Mechanistic investigation has confirmed that the source of oxygen is DMSO.

Microwave-assisted nickel(II) acetylacetonate-catalyzed arylation of aldehydes with arylboronic acids

Applying sealed vessel microwave heating at 180 °C in toluene the arylation of aromatic and aliphatic aldehydes with arylboronic acids using 1-2 mol % of Ni(acac)2 as a catalyst can be performed efficiently within 10-30 min providing the desired diarylmethanols or benzyl alcohols in good yields.