5617-32-3

Basic information

• Product Name: HEPTAETHYLENE GLYCOL
• Synonyms: 3,6,9,12,15,18-Hexaoxaeicosane-1,20-diol;3,6,9,12,15,18-Hexaoxaicosane-1,20-diol;HEPTAETHYLENE GLYCOL;2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol;HO-PEG7-OH;heptaMethelene glycol
• CAS NO: 5617-32-3
• Molecular Formula: C₁₄H₃₀O₈
• Molecular Weight: 326.38
• EINECS: 227-040-3
• Product Categories: Ethylene Glycols;Ethylene Glycols & Monofunctional Ethylene Glycols
• Mol File: 5617-32-3.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 244 °C / 0.6mmHg
• Flash Point: 216.9oC
• Appearance: /
• Density: 1.13
• Vapor Pressure: 2.14E-09mmHg at 25°C
• Refractive Index: 1.4653 (589.3 nm 20℃)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform, Ethyl Acetate (Sparingly)
• PKA: 14.06±0.10(Predicted)
• CAS DataBase Reference: HEPTAETHYLENE GLYCOL(CAS DataBase Reference)
• NIST Chemistry Reference: HEPTAETHYLENE GLYCOL(5617-32-3)
• EPA Substance Registry System: HEPTAETHYLENE GLYCOL(5617-32-3)

Safety Data

• Hazardous Substances Data: 5617-32-3(Hazardous Substances Data)

Usage

Description

Heptaethylene glycol contains repeating ethylene glycol subunits and two terminal hydroxyl groups. The hydroxyl groups can react to further derivatize the compound. The hydrophilic PEG linker increases the water solubility of a compound in aqueous media. The water solubility properties of the PEG linker are enhanced with longer PEG chains.

Uses

Heptaethylene Glycol is used for the preparation of large ring crown ether compounds.

InChI:InChI=1/C14H30O8/c15-1-3-17-5-7-19-9-11-21-13-14-22-12-10-20-8-6-18-4-2-16/h15-16H,1-14H2

Upstream product

• 107-21-1 ethylene glycol 
• 112-26-5 1,2-bis(2-chloroethoxy)ethane 
• 111-46-6 diethylene glycol 
• 101858-70-2 2,2-diphenyl-23-crown-8 
• 88099-81-4 2-methyl-23-crown-8 
• 5197-65-9 1,14-dichloro-3,6,9,12-tetraoxatetradecane 
• 144270-97-3 1,1,1,24,24,24-hexaphenyl-2,5,8,11,14,17,20,23-octaaoxatetracosane 
• 105891-53-0 1-((2-(2-(2-(2-(2-(2-(2-(benzyloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)methyl)benzene 
• 721918-44-1 [2-(2-{2-[2-(2-isopropoxycarbonylmethoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid isopropyl ester 
• 136824-79-8 heptaethylene glycol bis(allyl ether) 
• 4792-15-8 Pentaethylene glycol 
• 19249-03-7 triethylene glycol di-(p-toluenesulfonate) 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 112-60-7 Tetraethylene glycol 

Downstream Products

• 4486-31-1 heptakis(oxyethylene glycol)n-hexadecyl ether 
• 117095-88-2 4-phenyl-2,6-pyrido-27-crown-9 
• 33089-36-0 1,4,7,10,13,16,10-heptaoxacyclohenicosane 
• 122861-55-6 C₄₂H₈₄O₂₁ 
• 71092-60-9 42-Crown-14 
• 69502-27-8 2-[2-[2-[2-[2-[2-[2-(p-tolylsulfonyloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate 
• 1028089-05-5 Toluene-4-sulfonic acid 2-{2-[2-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethyl ester 
• 56930-39-3 1,20-dichloro-3,6,9,12,15,18-hexaoxatetradecane 
• 946533-36-4 C₂₉H₃₇BrN₂O₁₄ 
• 3386-18-3 nonaethylene glycol 
• 93593-89-6 4-Chloro-N-[2-(2-{2-[2-(2-{2-[2-(2-trimethylsilanyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-2λ⁵-benzo[1,3,2]dioxaphosphol-2-ylidene]-benzenesulfonamide 
• 1274892-60-2 2-{2-[2-(2-{2-[2-(2-azido-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethanol 

Relevant articles and documents

Highly efficient synthesis of monodisperse poly(ethylene glycols) and derivatives through macrocyclization of oligo(ethylene glycols)

A macrocyclic sulfate (MCS)-based approach to monodisperse poly(ethylene glycols) (M-PEGs) and their monofunctionalized derivatives has been developed. Macrocyclization of oligo(ethylene glycols) (OEGs) provides MCS (up to a 62-membered macrocycle) as versatile precursors for a range of monofunctionalized M-PEGs. Through iterative nucleophilic ring-opening reactions of MCS without performing group protection and activation, a series of M-PEGs, including the unprecedented 64-mer (2850Da), can be readily prepared. Synthetic simplicity coupled with versatility of this new strategy may pave the way for broader applications of M-PEGs. Macrocycles make synthesis easier: Convenient macrocyclization of the OEGs provides versatile macrocyclic sulfates. These compounds are cornerstones for both monofunctionalization of OEGs and highly efficient synthesis of monodisperse PEGs and derivatives, including an unprecedented 64-mer.

An expedient synthesis of monodispersed oligo(ethylene glycols)

A convenient approach to the synthesis of oligo(ethylene glycols) under phase transfer conditions is described. Oligo(ethylene glycols) (x = 7-12) are obtained in excellent yields and high purity via modular, bi-directional elongation of readily available ethylene glycol bis-tosylates.

Molecular motion in crown ethers. Application of 13C and 2H NMR to the study of 4-carboxybenzo-24-crown-8 ether and its KNCS complex in solution and in the solid phase

Large-amplitude solid phase molecular motion has been detected in the macrocyclic ring of the title crown either via 13C CPMAS NMR. To study the details of the dynamic processes, two selectively deuterated d4 derivatives have been prepared and examined via 2H NMR as a function of temperature. A phase change occurring around 277 K has been verified by differential scanning calorimetry (DSC) and a model for the motional processes has been developed involving equivalent two-site flips of the CD2 groups. The amplitude of the CD2 motions apparently decreases the closer the group is to the aromatic ring. The influence of KNCS complexation on the 13C CPMAS spectrum and on 13C spin lattice relaxation times in solution has been explored.