56177-96-9

Basic information

• Product Name: 3-(4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)propane
• Synonyms: 3-(4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)propane
• CAS NO: 56177-96-9
• Molecular Weight: 316.397
• Mol File: 56177-96-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-(4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)propane(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)propane(56177-96-9)
• EPA Substance Registry System: 3-(4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)propane(56177-96-9)

Safety Data

• Hazardous Substances Data: 56177-96-9(Hazardous Substances Data)

Upstream product

• 110047-50-2 1-(4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)propan-1-one 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 105686-91-7 (2E)-1-(4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one 
• 2675-79-8 1-bromo-3,4,5-trimethoxybenzene 

Downstream Products

• 102168-83-2 2,3,4-trimethoxy-6-[3-(4-methoxy-phenyl)-propyl]-benzaldehyde 

Relevant articles and documents

Syntheses of 2-methoxyestradiol and eugenol template based diarylpropenes as non-steroidal anticancer agents

Syntheses of 2-methoxyestradiol (1) and eugenol (6) template based conformationally flexible and rigid diarylpropenes, 14(a-l) and 20(a-e), as nonsteroidal anticancer agents have been performed. The synthesized compounds were evaluated for their anticance

Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: Synthesis and biological evaluation of antivascular activity

The α-methyl chalcone SD400 is a potent inhibitor of tubulin assembly and possesses potent anticancer activity. Various chalcone analogues were synthesized and evaluated for their cell growth inhibitory properties against the K562 human chronic myelogenous leukemia cell line (SD400, IC50 0.21 nM; combretastatin A4 CA4, IC50 2.0 nM). Cell cycle analysis by flow cytometry indicated that these agents are antimitotic (SD400, 83% of the cells are in G2/M phase; CA4 90%). They inhibit tubulin assembly at low concentration (SD400, IC50 0.46 μM; CA4, 0.10 μM) and compete with [3H]colchicine for binding to tubulin (8% [3H]colchicine remained bound to tubulin after competition with SD400 or CA4). Upon treatment with SD400, remarkable cell shape changes were elicited in HUVEC cells, consistent with vasculature damaging activity.