5618-62-2

Basic information

• Product Name: O-(2-Methylpropyl)hydroxylamine
• Synonyms: O-(2-Methylpropyl)hydroxylamine;O-Isobutylhydroxylamine
• CAS NO: 5618-62-2
• Molecular Formula: C₄H₁₁NO
• Molecular Weight: 89.14
• Mol File: 5618-62-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 118.4°C at 760 mmHg
• Flash Point: 24.4°C
• Appearance: /
• Density: 0.849g/cm³
• Vapor Pressure: 16.7mmHg at 25°C
• Refractive Index: 1.406
• PKA: 4.71±0.70(Predicted)
• CAS DataBase Reference: O-(2-Methylpropyl)hydroxylamine(CAS DataBase Reference)
• NIST Chemistry Reference: O-(2-Methylpropyl)hydroxylamine(5618-62-2)
• EPA Substance Registry System: O-(2-Methylpropyl)hydroxylamine(5618-62-2)

Safety Data

• Hazardous Substances Data: 5618-62-2(Hazardous Substances Data)

Usage

General Description

O-(2-Methylpropyl)hydroxylamine is a chemical compound with the molecular formula C4H11NO. It is comprised of a hydroxylamine functional group attached to a 2-methylpropyl group. The compound is primarily used as an intermediate in the synthesis of pharmaceuticals, pesticides, and other organic compounds. O-(2-Methylpropyl)hydroxylamine is a colorless to pale yellow liquid with a strong ammonia-like odor. It is considered to be a flammable and potentially hazardous chemical, requiring careful handling and storage. Additionally, it is important to note that O-(2-Methylpropyl)hydroxylamine may be sensitive to air and light, and should be kept in a cool, dry place away from direct sunlight.

InChI:InChI=1/C4H11NO/c1-4(2)3-6-5/h4H,3,5H2,1-2H3

Upstream product

• 513-38-2 Isobutyl iodide 
• 589-41-3 ethyl N-hydroxylcarbamate 
• 13259-29-5 sodium isobutoxide 
• 18498-63-0 N-isobutoxy-acetimidic acid ethyl ester 
• 63767-49-7 isobutoxycarbamic acid ethyl ester 
• 52026-51-4 O-1-(2-methyl)propyl-N-hydroxyphthalimide 

Downstream Products

• 55634-73-6 2-(1-Isobutoxyamino-propylidene)-5,5-dimethyl-cyclohexane-1,3-dione 
• 219778-40-2 5-bromo-3,4-difluoro-2-(4-iodo-2-methyl-phenylamino)-N-isobutoxy-benzamide 
• 6084-58-8 O-isobutylhydroxylamine hydrochloride 

Relevant articles and documents

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901

A novel series of benzhydroxamate esters derived from their precursor anthranilic acids have been prepared and have been identified as potent MEK inhibitors. 2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluoro-benzam ide, CI-1040, was the first MEK inhibitor to demonstrate in vivo activity in preclinical animal models and subsequently became the first MEK inhibitor to enter clinical trial. CI-1040 suffered however from poor exposure due to its poor solubility and rapid clearance, and as a result, development of the compound was terminated. Optimization of the diphenylamine core and modification of the hydroxamate side chain for cell potency, solubility, and exposure with oral delivery resulted in the discovery of the clinical candidate N-(2,3-dihydroxy-propoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-b enzamide PD 0325901.

Nodulisporic acid derivatives

The present invention relates to novel nodulosporic acid derivatives, which are acaricidal, antiparasitic, insecticidal and anthelmintic agents.