5620-22-4

Basic information

• Product Name: 2-hydroxy-N-(pyridin-3-ylmethyl)benzamide
• Synonyms: 2-hydroxy-N-(pyridin-3-ylmethyl)benzamide;2-hydroxy-N-(3-pyridylmethyl)benzamide;MFCD02934390
• CAS NO: 5620-22-4
• Molecular Formula: C₁₃H₁₂N₂O₂
• Molecular Weight: 228.25
• Mol File: 5620-22-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-hydroxy-N-(pyridin-3-ylmethyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-N-(pyridin-3-ylmethyl)benzamide(5620-22-4)
• EPA Substance Registry System: 2-hydroxy-N-(pyridin-3-ylmethyl)benzamide(5620-22-4)

Safety Data

• Hazardous Substances Data: 5620-22-4(Hazardous Substances Data)

Upstream product

• 3731-52-0 3-Aminomethylpyridine 
• 118-55-8 phenyl Salicylate 
• 69-72-7 salicylic acid 

Relevant articles and documents

A new group of potential antituberculotics: N-(2-pyridylmethyl) salicylamides and N-(3-pyridylmethyl)salicylamides

As a part of our systematic study of antimycobacterially active derivatives of salicylamides, a series of nineteen derivatives of N-(2-pyridylmethyl) salicylamides and N-(3-pyridylmethyl)salicylamides was synthesised. The compounds exhibited in vitro activity against Mycobacterium tuberculosis and M. avium. Their lipophilicity, RM, was measured by thin layer chromatography on silica gel impregnated with trioctadecylsilane and the logarithm of the partition coefficient (octanol-water), logP, was calculated. Both the parameters of lipophilicity correlated. The quantitative relationship between the structure and antimycobacterial activity was calculated. Antimycobacterial activity increased with an increase in lipophilicity. The N-(2-pyridylmethyl)salicylamide derivatives were more active than the derivatives of isomeric N-(3-pyridylmethyl)salicylamides. The geometry of compounds was calculated and the calculation was verified by measuring the length of the hydrogen bond between hydroxyl and carbonyl groups on the salicylic moiety.