56217-56-2

Basic information

• Product Name: 1,4-DIOXANE-2-CARBOXALDEHYDE
• Synonyms: 1,4-DIOXANE-2-CARBOXALDEHYDE;1,4-Dioxane-2-carboxaldehyde ,97%
• CAS NO: 56217-56-2
• Molecular Formula: C5H8O3
• Molecular Weight: 116.11522
• Mol File: 56217-56-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 194.1±25.0 °C(Predicted)
• Appearance: /
• Density: 1.220±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1,4-DIOXANE-2-CARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-DIOXANE-2-CARBOXALDEHYDE(56217-56-2)
• EPA Substance Registry System: 1,4-DIOXANE-2-CARBOXALDEHYDE(56217-56-2)

Safety Data

• Hazardous Substances Data: 56217-56-2(Hazardous Substances Data)

Usage

General Description

1,4-Dioxane-2-carboxaldehyde is a chemical compound also known as paraformaldehyde. It is a white crystalline solid with a formaldehyde-like odor. It is commonly used as a disinfectant and preservative in laboratory and medical settings. It is also used in the production of resins, plastics, and adhesives. 1,4-Dioxane-2-carboxaldehyde is known to be harmful if inhaled, ingested, or absorbed through the skin, and precautions should be taken when handling this chemical. It is important to use proper protective equipment and follow safety guidelines to minimize the risk of exposure to 1,4-Dioxane-2-carboxaldehyde.

Upstream product

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Relevant articles and documents

Meso-Tetra(dioxanyl)porphyrins: Neutral, low molecular weight, and chiral porphyrins with solubility in aqueous solutions

The synthesis of the low-molecular weight, meso-Tetra(dioxan-2-yl)porphyrin with considerable solubility in aqueous solution is described. The key intermediate dioxan-2-carbaldehyde is accessible in either racemic or in stereo-pure forms from commercially available starting materials in three steps. Using 4 × 1 or 2 + 2-Type syntheses provide the porphyrin in modest yields. While the racemic aldehyde created an intractable mixture of diastereomers, the enantiopure aldehyde created a single enantiomer of the target porphyrin. The porphyrin was spectroscopically characterized. As its free base or zinc complex, it showed excellent solubility properties in organic and aqueous solvents, though free water-solubility was not achieved. The work expands on the availability of chiral porphyrins and neutral porphyrins with considerable solubility in aqueous solution.

CONDENSED HETEROCYCLES AS BCL-2 INHIBITORS

The disclosure includes compounds of Formula (A) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, and R11, h, j, m, n, k, v, s, g, V, W, L, Z1 Q1, Q2, Q3, Q4, Q5, Q6, and Q7, are defined herein. Also disclosed is a method for treating a neoplastic disease, an autoimmune disease, or a neorodegenerative disease with these compounds.

HOT MELT EXTRUDED SOLID DISPERSIONS CONTAINING A BCL2 INHIBITOR

A pro-apoptotic solid dispersion comprises, a Bcl -2 family protein inhibitory compound of Formula A as defined herein, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier, and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises subjecting to elevated temperature the compound of Formula A, the water-soluble polymeric carrier, and the surfactant to provide an extrudable semi-solid mixture; extruding the semi-solid mixture; and cooling the resulting extrudate to provide a solid matrix comprising the polymeric carrier, and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl -2 family proteins, for example cancer or an immune or autoimmune disease.