5623-04-1

Basic information

• Product Name: 2-AMINO-N-HYDROXYBENZENECARBOXAMIDE
• Synonyms: 2-AMINO-N-HYDROXYBENZENECARBOXAMIDE;2-aminobenzohydroxamicacid;2-aminobenzoylhydroxylamine;2-amino-n-hydroxy-benzamid;2-amino-n-hydroxybenzamide;2-aminophenylhydroxamicacid;anthranilohydroxamicacid;n-anthranilohydroxamicacid
• CAS NO: 5623-04-1
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.15
• EINECS: 227-051-3
• Mol File: 5623-04-1.mol
• Article Data: 17

Chemical Properties

• Melting Point: 141-143°
• Appearance: /
• Density: 1.345g/cm³
• Refractive Index: 1.645
• PKA: 8.82±0.40(Predicted)
• CAS DataBase Reference: 2-AMINO-N-HYDROXYBENZENECARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-N-HYDROXYBENZENECARBOXAMIDE(5623-04-1)
• EPA Substance Registry System: 2-AMINO-N-HYDROXYBENZENECARBOXAMIDE(5623-04-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 5623-04-1(Hazardous Substances Data)

Usage

General Description

2-AMINO-N-HYDROXYBENZENECARBOXAMIDE, also known as paracetamol or acetaminophen, is a widely used over-the-counter pain reliever and fever reducer. It belongs to the class of drugs called analgesics and antipyretics. Paracetamol works by inhibiting the production of prostaglandins, which are chemicals in the body that cause pain and fever. It is commonly used to treat pain associated with headaches, muscle aches, arthritis, and menstrual cramps, as well as to reduce fever. Paracetamol is considered a safe and effective medication when used as directed, but it can cause liver damage if taken in large doses. It is important to read and follow the dosage instructions on the label carefully to avoid overdose.

InChI:InChI=1/C7H8N2O2/c8-6-4-2-1-3-5(6)7(10)9-11/h1-4,11H,8H2,(H,9,10)

Upstream product

• 134-20-3 2-carbomethoxyaniline 
• 4797-75-5 2-amino-N-(benzyloxy)benzamide 
• 118-92-3 anthranilic acid 
• 118-48-9 isatoic anhydride 
• 1138453-55-0 C₁₄H₁₂N₂O₄ 

Downstream Products

• 615-16-7 1,3-dihydro-2H-benzimidazol-2-one 
• 25940-12-9 2-furan-2-yl-3-hydroxy-2,3-dihydro-1H-quinazolin-4-one 
• 37795-71-4 3-methyl-2,3-dihydro-isoxazolo[3,2-b]quinazolin-9-one 
• 22166-62-7 o-Amino-benzoyl-aminoxy-essigsaeureethylester 
• 1010-70-4 3-hydroxy-2-methylquinazolin-4-one 
• 106910-73-0 N-Hydroxy-2-{[1-(2-hydroxy-naphthalen-1-yl)-meth-(E)-ylidene]-amino}-benzamide 
• 25940-05-0 3-hydroxy-2-(3-nitro-phenyl)-2,3-dihydro-1H-quinazolin-4-one 
• 25940-06-1 3-hydroxy-2-(4-nitro-phenyl)-2,3-dihydro-1H-quinazolin-4-one 
• 192512-89-3 2-phenyl-3-hydroxy-1,2-dihydroquinazolin-4-one 
• 192513-05-6 3-hydroxy-2-(2-hydroxyphenyl)-2,3-dihydroquinazolin-4(1H)-one 
• 25940-04-9 3-hydroxy-2-(2-nitro-phenyl)-2,3-dihydro-1H-quinazolin-4-one 
• 301152-31-8 2-(2-aminophenyl)-3-hydroxyquinazolin-4-(3H)-one 
• 400090-85-9 (2-amino-phenyl)-(2-oxa-3-aza-bicyclo[2.2.1]-hept-5-en-3-yl)-methanone 
• 28230-32-2 3-hydroxy-3,4-dihydrobenzotriazine-4-one 

Relevant articles and documents

Synthesis and antibiofilm evaluation of 3-hydroxy-2,3-dihydroquinazolin-4(1H)-one derivatives against opportunistic pathogen Acinetobacter baumannii

The emergence of multidrug resistant microorganisms has triggered the impending need for new aitimicrobial strategies. The antivirulence strategy with the benefite of alleviating the drug resistance becomes the focus of research. In this study, 22 quorum sensing inhibitors were synthesized by mimicking the structure of autoinducer and acinetobactin and up to 34% biofilm inhibition was observed with 5u. The biofilm inhibition effect was further demonstrated with extracellular polysaccharides inhibition and synergism with Gentamycin sulphate.

Synthesis and anticancer activity of new hydroxamic acid containing 1,4-benzodiazepines

By employing an intramolecular Pd(0)-mediated ring opening of an acylnitroso-derived cycloadduct, new hydroxamic acid containing benzodiazepines have been synthesized and have demonstrated biological activity in MCF-7 and PC-3 tumor cell lines. Subsequent

Monohydroxamic acids and bridging dihydroxamic acids as chelators to ruthenium(iii) and as nitric oxide donors: Syntheses, speciation studies and nitric oxide releasing investigation

The synthesis and spectroscopic characterisation of novel mononuclear RuIII(edta)(hydroxamato) complexes of general formula [Ru(H 2edta)(monoha)] (where monoha = 3- or 4-NH2, 2-, 3- or 4-Cl and 3-Me-phenylhydroxamato), as well as the first example of a Ru III-N-aryl aromatic hydroxamate, [Ru(H2edta)(N-Me-bha)] ·H2O (N-Me-bha = N-methylbenzohydroxamato) are reported. Three dinuclear RuIII complexes with bridging dihydroxamato ligands of general formula [{Ru(H2edta)}2(μ-diha)] where diha = 2,6-pyridinedihydroxamato and 1,3- or 1,4-benzodihydroxamato, the first of their kind with RuIII, are also described. The speciation of all of these systems (with the exception of the Ru-1,4-benzodihydroxamic acid and Ru-N-methylbenzohydroxamic systems) in aqueous solution was investigated. We previously proposed that nitrosyl abstraction from hydroxamic acids by Ru III involves initial formation of RuIII-hydroxamates. Yet, until now, no data on the rate of nitric oxide (NO) release from hydroxamic acids has been published. We now describe a UV-VIS spectroscopic study, where we monitored the decrease in the ligand-to-metal charge-transfer band of a series of RuIII-monohydroxamates with time, with a view to gaining an insight into the NO-releasing properties of hydroxamic acids. The Royal Society of Chemistry.