5623-46-1

Basic information

• Product Name: [4-(4-hydroxyphenyl)phenyl]-phenyl-methanone
• CAS NO: 5623-46-1
• Molecular Formula: C₁₉H₁₄O₂
• Molecular Weight: 274.319
• Mol File: 5623-46-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 457.9°Cat760mmHg
• Flash Point: 194.9°C
• Density: 1.186g/cm³
• CAS DataBase Reference: [4-(4-hydroxyphenyl)phenyl]-phenyl-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(4-hydroxyphenyl)phenyl]-phenyl-methanone(5623-46-1)
• EPA Substance Registry System: [4-(4-hydroxyphenyl)phenyl]-phenyl-methanone(5623-46-1)

Safety Data

• Hazardous Substances Data: 5623-46-1(Hazardous Substances Data)

Usage

Description

[4-(4-hydroxyphenyl)phenyl]-phenyl-methanone is a complex chemical compound characterized by a central methanone group connected to three distinct phenyl groups. One of these phenyl rings features a 4-hydroxyphenyl group, which may contribute to the compound's potential antioxidant and medicinal properties. Its unique structure and bioactivity make it a compound of interest for pharmaceutical research and drug development. However, further investigation is required to fully comprehend its characteristics and possible applications across different sectors.

Uses

Used in Pharmaceutical Research:
[4-(4-hydroxyphenyl)phenyl]-phenyl-methanone is used as a compound of interest for its potential antioxidant and medicinal properties, which may contribute to the development of new drugs and therapies.
Used in Drug Development:
In the field of drug development, [4-(4-hydroxyphenyl)phenyl]-phenyl-methanone is used as a starting point for designing and synthesizing novel pharmaceuticals, leveraging its unique structure and potential bioactivity to create new therapeutic agents.
Used in Antioxidant Applications:
Given its potential antioxidant properties, [4-(4-hydroxyphenyl)phenyl]-phenyl-methanone may be used as a component in the development of antioxidant products, which could have applications in various industries, such as cosmetics, food and beverages, and healthcare.
Used in Chemical Synthesis:
[4-(4-hydroxyphenyl)phenyl]-phenyl-methanone can be utilized as an intermediate or building block in the synthesis of more complex molecules, which could have applications in various chemical and material science industries.

Upstream product

• 68294-33-7 4-(4-methoxy-phenyl)-benzophenone 
• 101884-28-0 4-(4-nitro-phenyl)-benzophenone 
• 71969-79-4 4-(4-aminophenyl)-benzophenone 
• 2170-13-0 biphenyl 4-yl benzoate 
• 90-90-4 (4-bromophenyl)(phenyl)methanone 
• 36439-44-8 tetramethylammonium phenoxide 
• 139-02-6 sodium phenoxide 
• 1137-42-4 4-Hydroxybenzophenone 
• 124643-34-1 p-benzoylphenyl triflate 
• 19812-93-2 4-Cyano-4'-hydroxybiphenyl 
• 5720-07-0 4-methoxyphenylboronic acid 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 75-15-0 carbon disulfide 
• 7446-70-0 aluminium trichloride 

Downstream Products

• 68294-33-7 4-(4-methoxy-phenyl)-benzophenone 
• 913369-62-7 C₆H₅CHC₆H₄C₆H₄O 
• 93249-82-2 4-(4-acetoxy-phenyl)-benzophenone 
• 861096-89-1 4'-(hydroxydiphenylmethyl)biphenyl-4-ol 
• 622408-00-8 4'-(4''-hydroxyphenyl)-1,1-diphenylethylene 
• 622408-01-9 4'-(4''-methoxyphenyl)-1,1-diphenylethylene 
• 622407-99-2 4-(4'-methoxyphenyl)-α-methylbenzhydrol 
• 622408-03-1 4-hydroxy-4'-(α-hydroxybenzyl)biphenyl 
• 622407-98-1 4-(4'-hydroxyphenyl)-α-methylbenzhydrol 

Relevant articles and documents

Photogeneration and chemistry of biphenyl quinone methides from hydroxybiphenyl methanols

The photosolvolysis of several biphenyl methanols (Ph-PhCH[Ph]OH) substituted with hydroxy or methoxy groups on the benzene ring not containing the -CH(Ph)OH moiety has been studied in aqueous solution. This work is a continuation of our studies of photosolvolysis of hydroxy-substituted arylmethanols that generate quinone methide intermediates, some of which are known to be relevant intermediates in toxicology and in biological and organic chemistry in general. In this study, we further probe the ability of the biphenyl ring system to transmit charge from the ring substituted with a potential electron-donating group (hydroxy and methoxy) to the adjacent benzene ring that contains a labile benzyl alcohol moiety. We show that in systems with a hydroxy substituent, biphenyl quinone methides (BQM) are the first formed intermediates that are detectable by nanosecond laser flash photolysis, and are responsible for the observed overall photosolvolysis reaction of these compounds. The highly conjugated BQM are found to absorb at long wavelengths (λmax 580 and ～750 nm for the p,p′ and o,p′-isomers, respectively) with relatively long lifetimes in neutral aqueous solution (500 and 30 μs, respectively). The BQM from the o,p′-isomer was found to undergo a competing intramolecular Friedel-Crafts alkylation, to give a fluorene derivative.

Electrochemically Catalyzed Aromatic Nucleophilic Substitution. Phenoxide Ion as Nucleophile

Cyclic voltammetry and preparative-scale electrolysis of aryl halides in the presence of phenoxide ions, a nucleophile reputed as unreactive SRN1 reactions, show the formation, in liquid ammonia or in dimethyl sulfoxide, of coupling products along an electrochemically catalyzed SRN1 aromatic substitution process.Coupling occurs at carbons of the phenyl ring rather than at the phenolic oxygen.The mechanism of the reaction is estabilished on kinetic grounds.Determination of the coupling rate constant between phenoxide ions and aryl radicals and comparison with other n ucleophiles shows that phenoxide ions are quite efficient nucleophiles in SRN1 reactions.The reaction can as well be viewed as an homolytic aromatic substitution.Mechanistic implications concerning the latter type of reaction are discussed.With mediated electrochemical induction of the substitution reaction, it is possible to raise the yield in coupling product up to about 80percent, which renders the reaction an attractive route to the synthesis of electron donor-electron acceptor biaryls.