56242-66-1

Basic information

• Product Name: 2-Thiazolamine, N-cyclohexyl-4,5-dihydro-
• CAS NO: 56242-66-1
• Molecular Formula: C9H16N2S
• Molecular Weight: 184.305
• Mol File: 56242-66-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-Thiazolamine, N-cyclohexyl-4,5-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiazolamine, N-cyclohexyl-4,5-dihydro-(56242-66-1)
• EPA Substance Registry System: 2-Thiazolamine, N-cyclohexyl-4,5-dihydro-(56242-66-1)

Safety Data

• Hazardous Substances Data: 56242-66-1(Hazardous Substances Data)

Upstream product

• 1122-82-3 isothiocyanatocyclohexane 
• 84050-96-4 N₃-cyclohexyl-N₁-(2-methoxyethyl)-N₁-nitrosothiourea 
• 79645-05-9 N₃-cyclohexyl-N₁-(2-fluoroethyl)-N₁-nitrosothiourea 
• 84056-92-8 N₃-cyclohexyl-N₁-(2-hydroxyethyl)-N₁-nitrosothiourea 
• 79645-04-8 N₃-cyclohexyl-N₁-ethyl-N₁-nitrosothiourea 
• 84081-66-3 3-cyclohexyl-1-(2-methoxyethyl)thiourea 
• 81467-07-4 N-cyclohexyl-N'-(2-hydroxyethyl)thiourea 
• 32900-12-2 3-cyclohexyl-1-ethylthiourea 
• 87191-83-1 3-cyclohexyl-1-(2-chloroethyl)thiourea 
• 33024-70-3 1-cyclohexyl-3-(2-fluoroethyl)thiourea 
• 80672-59-9 chlorhydrate de N-(thiazolin-2 yl-2) cyclohexylamine 
• 108-91-8 cyclohexylamine 
• 40836-94-0 2-methylsulfanyl-4,5-dihydrothiazoline hydroiodide 
• 151-56-4 ethyleneimine 

Downstream Products

• 87191-81-9 2-(cyclohexylimino)-3-nitrosothiazolidine 

Relevant articles and documents

New 2-Aminothiazoline derivatives lower blood pressure of spontaneously hypertensive rats (SHR) via I1-imidazoline and alpha-2 adrenergic receptors activation

2-Aminothiazolines share an isosteric relationship with imidazolines and oxazolines with antihypertensive activity mainly mediated by the imidazoline I1-receptor. In the present work, we have prepared five aminothiazolines, following a previously described synthetic pathway. Aminothiazolines derived from dicyclopropylmethylamine (ATZ1) and cyclohexylamine (3) are unprecedented in the literature. Competitive radioligand assay was carried out with all synthetic compounds, and the I1receptor affinity in comparison to rilmenidine in PC12 cells was determined. Surprisingly, the rilmenidine isoster (ATZ1) showed no I1-receptor interaction. Diethyl (ATZ4) and 2-ethyl-hexylamine (ATZ5) derivatives bind to the receptor with 11.98 and 10.94 nmol/l, respectively. These compounds were selected for in vivo experiments. Both compounds reduced the blood pressure of spontaneously hypertensive rats (SHR). The hypotensive effect of these compounds was abrogated in the presence of α2adrenergic (yohimbine) and I1(efaroxan) receptor antagonists suggesting that both aminothiazolines bind to the adrenergic and imidazoline receptors. Lipinski's descriptors of the synthesized aminothiazolines were calculated and are similar to the known imidazoline I1receptor ligands. 3D-Similarity between ATZ5 and agmatine, the natural imidazoline receptor ligand, was also observed.

Nitrosation of 2-Arylamino- and Alkylamino-2-thiazolines

The N-nitrosation of 2-arylamino- and alkylamino-2-thiazolines gives the exocyclic or endocyclic nitrosated products depending on the nature of reagents used.The structures of these nitrosoproducts have been confirmed by PMR and 13C NMR spectral data.